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Antioxidant Flavonoids Bind DNA and RNA at Multiple Sites pp. 331-346 $100.00
Authors:  (Sh. Nafisi, Bariyanga, H. A. Tajmir-Riahi, Department of Chemistry, Azad University, Central Tehran Branch, Shahrake Gharb, Sanat Square, Tehran, Iran, and others)
Abstract:
Flavonoids are natural polyphenolic compounds with major antioxidant activity that can prevent DNA damage. The anticancer and antiviral activities of these natural products are attributed to their potential biomedical applications. In this chapter, we are examining how the antioxidant flavonoids bind DNA and RNA and what mechanism of action is involved in preventing DNA damage. Detailed spectroscopic data on the interactions of morin (mor), apigenin (api), naringin (nar), quercetin (que), kaempferol (kae) and delphinidin (del) with DNA and transfer RNA in aqueous solution at physiological conditions were analysed. The structural analysis showed flavonoids mainly intercalate into DNA and RNA duplexes with minor external binding to the major or minor groove and the backbone phosphate group. The stability of adduct formation is in the order of que>api>kae>del>mor>nar for DNA and del> api>que>kae>nar>mor for tRNA. Low flavonoid concentration induces helical stabilization, whereas high pigment content causes helix opening. Flavonoids induce a partial B to A-DNA transition at high pigment concentration, while tRNA remains in A-family structure upon flavonoid complexation. The antioxidant activity of flavonoids changes in the order delphinidin>quercetin>kaempferol>morin> naringin>apigenin. The results show intercalated flavonoid molecule can act as an antioxidant and prevent DNA damage. 


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Antioxidant Flavonoids Bind DNA and RNA at Multiple Sites pp. 331-346