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Diterpenes: An Approach against Cariogenic Gram Positive Bacteria pp. 251-270 $100.00
Authors:  (Sérgio R. Ambrósio, Rodrigo C. S. Veneziani, Carlos H. G. Martins, Vladimir C. G. Heleno, Niege A. J. C. Furtado, Wilson R. Cunha, Núcleo de Pesquisa em Ciências, Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil, and others)
Dental caries is a common oral bacterial pathology caused by a biofilm consisting of microorganisms adhered on the tooth surface, which may cause demineralization of tooth hard tissues and teeth loss. It has been experimentally demonstrated that Streptococcus mutans is responsible for the beginning of the caries process, being followed by other aerobic bacteria such as Enterococcus faecalis, Lactobacillus casei, Streptococcus mitis, Streptococcus sanguinis, Streptococcus sobrinus and Streptococcus salivarius. The mechanical removal of the dental plaque is the most efficient procedure to prevent caries; however, the use of chemicals as a complementary measure is also necessary and has demonstrated to be of great value with respect to decreasing the tooth surface biofilm. Nowadays, chlorhexidine is considered a gold standard anticariogenic and has received the approval of the American Dental Association Council on Dental Therapeutics. However, the regular use of oral care products containing this chemical are often associated with tooth and restoration staining, changes in the taste of food, and a burning sensation at the tip of the tongue. In addition, clorhexidine is much less effective in reducing the levels of Lactobacillus, which are strongly related to caries evolution. These problems, therefore, denote that finding new effective anticariogenic compounds is mandatory. Natural products, especially those derived from higher plants, have provided a promising source for the discovery of novel biologically lead molecules. Several classes of secondary metabolites are synthesized by plants and, among them, diterpenes are recognized as a class with a wide spectrum of biological activities, including their significant antibacterial activity. 

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Diterpenes: An Approach against Cariogenic Gram Positive Bacteria pp. 251-270