Pleuran: Immunomodulotor Polysaccharide from Pleurotus ostreatus, Structure, Production and Application pp. 153-172
Authors: (Hesham El Enshasy, Parisa Maftoun, Roslinda Abd Malek, Institute of Bioproducts Development (IBD), Universiti Teknologi Malaysia (UTM), Johor, Malaysia, and others)
Abstract: Traditionally mushrooms are considered in daily diet, especially in the orient as they are rich in nutrition and have abundant therapeutic properties. Nowadays large scale mushroom cultivation takes attention of many pharmaceutical companies around the world due to their rich and variety of medicinal compounds. Extensive research in isolation, characterization and production of these biological components is conducted in last decades. Among them numerous studies are dedicated to polysaccharide production as they exhibit immunomodulator and anti-tumor activities. Glucan with different active unit linkage such as (1→3), (1→6)-β-glucan and (1→3)-α- glucans constitute mushroom polysaccharides which perform immunomodultor activity as they are biological response modifiers (BRMs). Beta-glucan obtained from the Pleurotus ostreatus (Oyster mushroom) is known in the scientific literature as pleuran. It is structural cell wall compound. It stimulates the body´s defense system against infections (bacterial, viral, yeast, and parasitic) and modulates the blood producing activity of bone marrow. In this chapter we are going to focus on the structure of pleuran, followed by its production strategies. Furthermore the therapeutic application of pleuran will be demonstrate and are for further researched will be suggested.