Microwave-Assisted Catalytic Asymmetric Transformations pp. 281-294
Authors: (Carolina Vargas, Alina Mariana Balu, Juan Manuel Campelo, Maria Dolores Gracia, Elia Losada, Rafael Luque, Antonio Pineda, Antonio Angel Romero, Departamento de Tecnología Química y Ambiental, Universidad Rey Juan Carlos, Móstoles, Madrid, Spain, and others)
Abstract: Environmental and economical considerations in past decades have urged scientists to redesign commercially important processes towards the use of more environmentally friendly substances avoiding the use of toxic compounds and generation of waste. In this way, the substitution of conventional heating by microwave irradiation as an alternative source of energy is increasingly attractive. Microwave-assisted heating is particularly interesting because it offers improved conversions (and often seletivities to target products) under milder conditions at remarkably reduced times of reaction for a wide range of conventional reactions. In this chapter we aim to explore several asymmetric syntheses carried out under microwave irradiation, giving a general overview of recently developments in this field. Significant rate enhancements, a decrease of chiral catalyst loading and higher enantioselectivities are the key achievement of microwave activation protocols.