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Role of the Actin Cytoskeleton in Tumor Escape to Immune System and Acquisition of Tumor Resistance to Cytotoxic Treatment pp. 245-255 $100.00
Authors:  (Rania Zaarour, Fui Goh, Meriem Hasmim, Bassam Janji, Salem Chouaib, University Of Sharjah, College of Medicine, Department of Basic Medical Sciences, Sharjah, United Arab Emirates, and others)
Abstract:
Cancer cell survival is a fundamental process essential for cancer related mortalities. This
process could be related either to a defect in the immune system machinery or to an acquiring
of survival properties by cancer cells allowing them to survive despite a functional immune
system. How a cancer cell survives in an environment where competent immune cells are
present remains an important question. Understanding basic mechanisms of tumor-host
immune interactions will shed light on developing methods to eradicate tumor cell survival, to
attenuate immunotherapy resistance and to develop targeted anti-cancer drugs. Actin and
tubulin form highly versatile, dynamic polymers that can organize cytoplasmic organelles and
intracellular compartments, define cell polarity, and generate both pushing and contractile
forces. Therefore, it is not surprising that they are key players in many processes in cell
biology. Accumulating evidence involve the actin cytoskeleton at the core of this question.
Indeed, the cytoskeleton plays an essential role in regulating a plethora of molecular events
that ultimately lead to death resistance by cancer cell. In this regard, cytoskeletal remodeling
has been described to be responsible for the resistance of cancer cells to cytotoxic immune
cell attack as well as in the activation of the attack by immune cells. In this chapter we focus
on the role of the actin cytoskeleton in the processes of regulating T cell activity and evading
T lymphocyte mediated killing events. 


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Role of the Actin Cytoskeleton in Tumor Escape to Immune System and Acquisition of Tumor Resistance to Cytotoxic Treatment pp. 245-255