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Novel Ultradispersed Carbon-Containing Adsorbent: The Examples of the Study of Some Glycopeptide Antibiotics Sorption Properties on the Sorbent (pp. 43-66) $100.00
Authors:  (G.S. Katrukha, A.V. Timofeeva, V.N. Buravtsev, I.V. Tolstykh, L.A. Baratova, Belozersky Research Institute of Physicochemical Biology, Moscow State University, Moscow, Russia)
Abstract:
The development of thermally treated modified graphite sorbents has now made a great progress in Russia. The novel ultradispersed carbon-containing adsorbent (UDUS) was developed in the Laboratory for Biophysics of Substance Ultradisperse Forms of Dept of Substance Structure of the Institute for Chemical Physics, Russian Academy of Sciences. It was based on the modified oxygen-containing graphite (MOG) and the method of its production. But the MOG can not be used in medical practice because of its high toxicity (it contains 2-3% Al and up to3-5% Fe in residue). The newly obtained UDUS lacks of these impurities and can be used for detoxication and sterilization of human biological liquids as well as for cleaning and sterilization of fluid and gaseous media. In recent publications, the efficiency of using UDUS for sorption from water solutions of such macromolecular biological particles as influence viruses A and B was demonstrated. A possibility of its application for medical purposes as a decontamination of viruses containing solutions was indicated.
Our special interest was use of the UDUS as a potential sorbent for antibiotics isolation from culture liquid (CL) of the producing strain after a fermentation process. That is why we began with investigation of UDUS sorption characteristics concerning the standards of the clinically important glycopeptide group which contains such well-known
antibiotics as vancomycin, ristomycin A, teicoplanin A2, eremomycin. Antibiotics of that group are used in chemotherapy for treatment infectious disease caused by polyresistant gram-positive microorganisms such as Staphylococcus aureus (MRSA), Methycillin-resistant Staphylococcus epidermidis (MRSE), Clostridium difficile, Enterococci, Pneumococci, etc. But, the treatment with the above mentioned antibiotics induces adverse side effects, the frequency of their appearance being determined by low quality of injection forms purification. Therefore the search for efficient methods of the purification is necessary. One of the way to achieve this aim is to find a new efficient sorbent. The first times the absorption capacity of the UDUS towards the studied antibiotics and the conditions for their intense adsorption was determined. Besides, a mathematical model for the kinetics of glycopeptides antibiotics adsorption on the UDUS was suggested. It agrees well with obtained experimental data defining optimal conditions for the sorption glycopeptides antibiotics from solutions. However, it is insufficient to study the UDUS sorption characteristics for using it as a sorbent. It is important also to investigate the process of antibiotics desorption from the UDUS. It was shown that various combinations of organic solvents (THF, t-BuOH, i-PrOH, DMSO) were capable of eluting these antibiotics. The physic- chemical properties and antimicrobial activities of the desorbed antibiotics were unchanged. As a result of the investigations, it was found that the UDUS can be used in practice for isolation and purification antibiotics of the polypeptide group from solutions.
High adsorption capacity of the UDUS regarding glycopeptides antibiotics allows one to put forward that the sorbent can serve as a matrix for isolation antibiotics from solutions and obtaining stable complexes of the UDUS-antibiotics type. The application of such drugs in medical practice has to increase bioavailability of antibiotics and directivity of their delivery to the site of disease centers. It follows from the above that the results of present investigation are of both practical and theoretical importance. The obtained complexes the UDUS-antibiotics may become in perspective a novel generation of drugs 


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Novel Ultradispersed Carbon-Containing Adsorbent: The Examples of the Study of Some Glycopeptide Antibiotics Sorption Properties on the Sorbent (pp. 43-66)