Rheumatoid Arthritis: Present and Future (pp.1-46)
Authors: (F.J. Salgado, A. Canda-Sánchez, M.P. Arias, S. Vázquez, M. Nogueira, Department of Biochemistry and Molecular Biology, CIBUS, Centre for Biologigal Research of the USC, University of Santiago de Compostela, USC, A Coruña, Spain)
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology that originates a great functional damage, reduction of the quality/ life expectancy and great economical impact. RA is the most frequent chronic inflammatory disorder, affecting millions of people worldwide. This heterogeneous disease is characterized by a fluctuating clinical course, and patients may even experience long periods without symptoms. Although the RA treatment has radically changed with the advent of the biological therapies that include conventional as well as biologic agents, a number of important questions, like optimal dosing, elusive goal of personalized therapy and an evaluation of the real impact of biologic therapy on patient’s life, are not completely understood yet. Today, the most challenging issue in RA is the identification of biomarkers for early disease diagnosis, prognosis of disease outcome and prediction of therapeutic responses.
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