Incidence, Predictors and Management of Restenosis after Percutaneous Revascularization for Left Main Coronary Disease (pp.189-204)
Authors: (Ahmed Rezq, Giuseppe Biondi-Zoccai, Giuseppe Sangiorgi, Division of Cardiology, University of Modena and Reggio Emilia, Modena, Italy, and others)
Abstract: Percutaneous coronary intervention is a mainstay in the management of coronary artery disease, yet its role for patients with significant stenosis of the unprotected left main stem has always been debated. The SYNergy between PCI with TAXUS and cardiac surgery (SYNTAX) trial and similar randomized and non-randomized studies have provided much awaited evidence in favor of percutaneous drug-eluting stenting for this challenging lesion. However, even drug-eluting stents may be fraught with in-stent or in-segment neointimal hyperplasia, leading to restenosis and reintervention. We thus aimed to comprehensively and systematically review the incidence, predictive factors and management strategies for restenosis occurring after percutaneous coronary intervention with stent implantation in the unprotected left main coronary stem.