The Role of Genetics in the Susceptibility to Restenosis (pp.221-232)
Authors: (Gilberto Vargas-Alarcón, José Manuel Fragoso, Marco Antonio Peña-Duque, Marco Antonio Martínez-Ríos, Department of Molecular Biology and Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico)
Abstract: In the 20th century, coronary artery disease (CAD) was the major cause of morbidity and mortality in the world, and World Health Organization statistics demonstrate that this trend will continue well into the future. The treatment strategies are coronary artery bypass grafting, percutaneous transluminal coronary angioplasty (PTCA), and intracoronary stent. However, after PTCA, restenosis occurs in about 30 to 32% of patients and after intracoronary stent placement in 12 to 32% of patients.
Several reports have demonstrated that genetic factors may be involved in the pathogenesis of restenosis after PTCA and in-stent restenosis. However, in some cases inconsistent results in different populations have been reported. In this review the role of several candidate genes involved in the pathogenesis of restenosis are discussed.