Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Cell Biology » Autophagy: Principles, Regulation and Roles in Disease Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Doxycycline: Medical Uses and Effects
$82.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Diverse roles of autophagy in immunity (pp.3-24)
Tell A Friend
 
Tell someone you know about this product.
Diverse roles of autophagy in immunity (pp.3-24) $100.00
Authors:  (Ian X. McLeod, Wei Jia, and You-Wen He)
Abstract:
Autophagy is a highly conserved process in all eukaryotic organisms that has been adapted for a multitude of divergent functions. The mammalian immune system is no exception, with various hematopoietic cells utilizing this intracellular remodeling process for immune homeostasis.
In this chapter, we will focus on the role of autophagy in three major areas of immune function: homeostasis of lymphocytes, antigen presentation and pathogen clearance, and thymic selection for immune tolerance.
First, autophagy has been shown to be crucial and indispensible for the survival and intracellular homeostasis of both T and B lymphocytes in vivo.
This has been demonstrated using multiple genetic models of autophagy ablation as well as pharmacological inhibition of various autophagic signaling pathways. Second, autophagy has been shown to enhance antigen presentation in several types of leukocytes of the innate immune system, including macrophages and dendritic cells, and to both promote and inhibit the clearance of several intracellular pathogens.
Lastly, in a very nascent field of autophagy in thymic epithelial cells, autophagy promotes the processing and surface display of many endogenous antigens in order to influence negative selection and tolerance of developing thymocytes. These examples will clearly demonstrate the complex applications that the panoply of immune cells has evolved to initiate and maintain immune function using an archaic process found in the most primal of eukaryotes. 


Available Options:
Version:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2021

Diverse roles of autophagy in immunity (pp.3-24)