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Autophagy pathways and drug targets for cancer therapy (pp.111-154) $100.00
Authors:  (Huai-long Xu, Lei-lei Fu, Yu Yang, Bo Liu, Xu Zhao, Wen-wen Li, Jin-ku Bao)
Autophagy is evolutionarily conserved lysosomal mechanism mediating a variety of vital homeostatic processes, such as stress responses, remodeling, differentiation, secretion, innate and adaptive immune responses, as well as cell death. Therefore, it is not surprising the presence of a growing scientific interest in the role of autophagy in pathogenesis of a wide range of diseases, particularly of cancer. The autophagy is a multistage complex process and many of its pathways remain obscured. However, key regulatory elements such as autophagy-related genes (ATGs), class I and III PI3kinases, mTOR and p53 are suggested to be crucial in control of regulation of autophagic process in cancer. Often autophagy is portrayed as two-face Janus, facing opposite directions: past and future, death and life. This dual role of autophagy in determining the destiny of cancer cells makes it an attractive target for treatment with anti-cancer drugs such as a former one, rapamycin, and more recent tamoxifen, imatinib, gefitinib and chloroquine. In this light, a predictive analysis of potential targets for regulation of autophagy in cancer cells may give a fundamental basis for anticancer drug development. 

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Autophagy pathways and drug targets for cancer therapy (pp.111-154)