Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Cell Biology » Autophagy: Principles, Regulation and Roles in Disease Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Doxycycline: Medical Uses and Effects
$73.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Autophagy pathways and drug targets for cancer therapy (pp.111-154)
Tell A Friend
 
Tell someone you know about this product.
Autophagy pathways and drug targets for cancer therapy (pp.111-154) $100.00
Authors:  (Huai-long Xu, Lei-lei Fu, Yu Yang, Bo Liu, Xu Zhao, Wen-wen Li, Jin-ku Bao)
Abstract:
Autophagy is evolutionarily conserved lysosomal mechanism mediating a variety of vital homeostatic processes, such as stress responses, remodeling, differentiation, secretion, innate and adaptive immune responses, as well as cell death. Therefore, it is not surprising the presence of a growing scientific interest in the role of autophagy in pathogenesis of a wide range of diseases, particularly of cancer. The autophagy is a multistage complex process and many of its pathways remain obscured. However, key regulatory elements such as autophagy-related genes (ATGs), class I and III PI3kinases, mTOR and p53 are suggested to be crucial in control of regulation of autophagic process in cancer. Often autophagy is portrayed as two-face Janus, facing opposite directions: past and future, death and life. This dual role of autophagy in determining the destiny of cancer cells makes it an attractive target for treatment with anti-cancer drugs such as a former one, rapamycin, and more recent tamoxifen, imatinib, gefitinib and chloroquine. In this light, a predictive analysis of potential targets for regulation of autophagy in cancer cells may give a fundamental basis for anticancer drug development. 


Available Options:
Version:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2021

Autophagy pathways and drug targets for cancer therapy (pp.111-154)