Autophagy in the eye: a double-edged sword (pp.157-180)
Authors: (Goran Petrovski, Réka Albert, Kai Kaarniranta, Morten C. Moe, László Fésüs, András Berta, Dipak K. Das)
Abstract: Autophagy, a cytoplasmic recycling process active from early development throughout lifetime and aging has turned from largely a morphological phenomenon to a well described molecular mechanism in health and disease. The eye as an organ in which an interplay of three germ layers is responsible for achieving complex visual response, is the place where battles for cellular life or death takes place continuously – an organ in which the highest dead cell turnover occurs in the human body. The role of autophagy in the different segments of the eye remains not so well understood or described, making it difficult to classify autophagy as a protective or disease causing process. This chapter
summarizes the current knowledge about the role of autophagy in eye health and disease as well as the present drug targets applying autophagy as a protective mechanism against ophthalmic neurodegeneration and aging.