Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Physiology » Photoreceptors: Physiology, Types and Abnormalities Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Theory of Literature
$243.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Retinal Photoreceptor Cells: Phototransduction Mechanisms in Health and Disease (pp. 79-96)
Tell A Friend
 
Tell someone you know about this product.
Retinal Photoreceptor Cells: Phototransduction Mechanisms in Health and Disease (pp. 79-96) $100.00
Authors:  (Maria Ana Contín, Milagros M. Arietti, Mario E. Guido, Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC) CONICET, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba, República Argentina)
Abstract:
The retina is the part of the central nervous system adapted to the initial capture and processing of visual signals. However, its organization makes it vulnerable to dysfunction. Retinitis pigmentosa (RP) is a group of dystrophies that leads to retinal degeneration and eventually blindness. In most typical cases the rods are the predominantly affected cells in the retina, generating symptoms including night blindness, bilateral symmetric loss of the mind-peripheral visual field, or/and electroretinographic (EGR) abnormalities. Some forms of RP kill the photoreceptor cells, causing visual damages ranging from mild (in night blindness) to severe visual impairment owing to the high rate and constitutive activation of the phototransduction process. The question therefore arises as to why phototransduction causes cell death.
A powerful approach to the understanding of etiologies of visual impairment at the cellular and molecular levels has been the use of experimental animal models that mimic the damage caused in human pathologies for a number of inherited retinal diseases, by exposing animals carrying specific retinal gene mutations or wild-type animals to continuous light treatment.
The death of photoreceptor cells induced by low light intensity requires the activation of photopigments and a consequent downstream signal transduction cascade. Light exposure has therefore served as a model for human retinal degeneration arising
from environmental insult and genetic disease. In this chapter we will discuss the different retinal degenerations related to retinitis pigmentosa (RP) disease, with special emphasis on those caused by genetic defects, vitamin A deficiency or prolonged light exposure producing the constitutive activation of the phototransduction pathway. We will also examine the mechanisms of apoptotic death occurring after retinal light damage and provide insight into the positive and negative aspects of retinal degeneration models. We consider that the molecular mechanism taking place in damage caused by low light intensity can provide valuable experimental models for studying the effects of clinical genetic disorders related to defects in the phototransduction mechanism. 


Available Options:
Version:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Retinal Photoreceptor Cells: Phototransduction Mechanisms in Health and Disease (pp. 79-96)