The Salmonella Pathogenicity Island Encoded Type III Secretion Systems and their Role in Infection of Poultry (pp. 39-75)
Authors: (Taseen Desin, Amanda Wisner, Aaron White, Andrew Potter, Wolfgang Köster, Vaccine & Infectious Disease Organization, University of Saskatchewan, Canada)
Abstract: Many strains of Salmonella enterica represent oonotic pathogens which are capable of causing disease in humans. One major source of food poisoning is Salmonella enterica serovar Enteritidis which is often found associated with chicken meat, meat products and eggs. A number of virulence factors enable this bacterium to colonize and systemically infect poultry. In this review we will concentrate on the S. Enteritidis Type III Secretion System (T3SS) located on Salmonella Pathogenicity Island-1 and highlight its role in invasion of chickens. The structural components of the complex secretion apparatus and the secreted effector proteins will be introduced. Aspects of T3SS assembly, its expression regulation under different conditions as well as its involvement in colonization and invasion of poultry will be discussed in the context of the recent findings.