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Functional Neurology and Immunology: IV. Natural Killer, T-Cell and B-Cell Function in Health and Disease (pp. 461-483) $40.00
Authors:  Aristo Vojdani and Jama Lambert
Abstract:
NK cells have the capacity to modulate the adaptive immune system through direct cell-cell interaction, granular release or by cytokine production, which are instrumental in the killing of malignant cells. They also play a vital role in the regulation of immune responses and many other biological processes. In the late 1980s the senior authorís post-doctoral research coupled with other studies led to the conclusion that NK cells mediate elimination of cancer cells and prevent cancer from developing and spreading to distant tissues. Extensive testing in patients with various cancers progressed logically to the idea that the number and functions of NK cells in blood positively correlate with the individualís resistance to cancer development and, therefore, may serve as prognostic markers. Later studies with autistic children, patients of various diseases, and soldiers suffering from Gulf War syndrome confirmed that the number and function of NK cells appear to be affected by environmental factors, stress, alcohol, toxic chemicals, and viral diseases. If environmental stressors affect immunological and neurological messengers, the recognition process may break down, leading to suppression of NK cellsí activity or their malfunction, possibly turning their destructive power on non-inimical cells, leading to autoimmunity. Another contributor to autoimmunity is the lymphopenia-induced homeostatic proliferation of autoreactive T cells, B cells and many mediators. Like NK cells, these important components of the immune system are subject to the effects of environmental factors, such as mercury contamination or EBV infection. There is evidence that EBV infection is part of the mechanism that facilitates the invasion of autoreactive T and B cells into the central nervous system. This further strengthens the bi-directional association between nervous system and immune system and the conclusion that any environmental factors affecting the brain can affect the immune system, and, conversely, any factors affecting the immune system can affect the functions of the brain. 


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Functional Neurology and Immunology: IV. Natural Killer, T-Cell and B-Cell Function in Health and Disease (pp. 461-483)