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Propolis: Therapeutic Perspectives Against Silica Induced Toxic Manifestations (pp. 155-172) $100.00
Authors:  (Monika Bhadauria, Satendra Kumar Nirala, Amita Jaswal, Suchita Raghuvanshi, Renu Bhatt and Sangeeta Shukla)
Silica is one of the most documented workplace contaminants. Long-term
occupational exposure to silica is associated with an increased risk for respiratory
diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary
disease and lung cancer. Protective role of propolis extract (200 mg/kg, po) was
evaluated against silica (SiO2; 40 mg/kg; ip for 6 weeks) induced subchronic toxic
manifestations in liver, kidney and lung and effectiveness was compared with positive
control silymarin. Toxicological consequences were evident by decreased hemoglobin
and enhanced level of serum transaminases, alkaline phosphatase, angiotensin converting
enzyme, protein, cholesterol, creatinineand blood sugar after exposure to silica. Tissue
biochemistry revealed raise in acid phosphatase, whereas fall in alkaline phosphatase,
adenosine triphosphatase, total protein and glycogen content in liver, kidney and lung
after silica toxicity. Hepatic glucose-6-phosphatase was found to be decreased after silica
administration. Significant raise in lipid peroxidation and decreased level of reduced
glutathione, super oxide dismutase and catalase showed oxidative stress consequences in
these organsafter silica exposure. Propolis extract showed therapeutic potential and
reverses silica induced oxidative stress and biochemical alterations in liver, kidney and
lungs. Silica intoxication inhibited the activity of aniline hydroxylase of CYP2E1
enzymes, and enhanced peroxidative damage in hepatic microsomal fraction. Conjoint
treatment of propolis protected alteration in aforesaid biochemical variables significantly
and preferred histological features of liver, kidney and lung towards control. In this
chapter, we advocate the therapeutic perspective of propolis against silica induced toxic

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Propolis: Therapeutic Perspectives Against Silica Induced Toxic Manifestations (pp. 155-172)