Book Description:
COX-2 Inhibitors are newly developed drugs for inflammation that selectively block the COX-2 enzyme. Blocking this enzyme impedes the production of the chemical messengers (prostaglandins) that cause the pain and swelling of arthritis inflammation. Cox-2 inhibitors are a new class of nonsteroidal anti-inflammatory drugs (NSAIDS). Because they selectively block the Cox-2 enzyme and not the Cox-1 enzyme, these drugs are uniquely different from traditional NSAIDS. This new book explores new research in this field.

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Table of Contents:
Preface;

Chapter 1. Cyclooxygenase-2 Inhibitor and Gastric Cancer, pp. 1-83
(Yumin Li, Raaj K Praseedom, and Andrew Butler et al., University of Cambridge, UK).

Chapter 2. Prevention and Chemoprevention of Gastric Cancer: Dietary Habits, Helicobacter pylori and COX-2 Inhibitors, pp. 85-114
(Gerardo Nardone and Alba Rocco, University ”Federico II, Italy).

Chapter 3. Cyclooxygenases in Cancer, pp. 115-143
(Daniela Fodera, and Nadia Lampiasi, Instituto di Biomedicina e Immunologia Molecolare “Alberto Monroy”, Italy and Antonella Cusimano et al., Universita di Palermo, Italy).

Chapter 4. Nephrotoxicity of Nonsteroidal Anti-Inflammatory Drugs: Focus on Selective Cyclooxygenase-2 (COX-2) Inhibitors, pp. 145-180
(Steven G. Coca and Mark A. Perazella, Yale University School of Medicine, CT).

Chapter 5. Are COX-2 Inhibitors Active on Intracellular Oxidative Processes? A Study on In Vitro and Cellular Models, pp. 181-207
(Ange Mouithys-Mickalad, Ginette Deby-Dupont, and Carol Deby et al., Institute of Chemistry, Belgium).

Chapter 6. Theoretical Mechanism Studies on Dual Inhibition of Human Cyclooxygenase-2 and 5-Lipoxygenase by Diaryl-Pyrrolizine Derivatives, pp. 209-235
(R. Pouplana, C. Perez, and J. Ruiz, Universitat de Barcelona, Spain).

Index.