The Functional Role of Cerebral ATP Levels in Body Weight Regulation (pp. 143-160)
Authors: (Kamila Jauch-Chara, Kerstin M. Oltmanns, Division of Psychoneurobiology, Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany)
Abstract: Adenosine triphosphate (ATP) is ubiquitously used for intracellular chemical energy
transfer processes in the entire organism. Within the brain, however, ATP takes on a
special functional role, which exceeds by far its peripheral mission as local cellular
energy supplier. Neuronal ATP levels exert a dominating influence on downstream
metabolic systems regulated by corresponding functional brain areas and therefore
control decisive factors of the organismic energy homeostasis such as energy expenditure
and food intake behavior. The first part of this chapter outlines i) how physiological brain
energy supply for ATP synthesis occurs, ii) the function of ATP-sensitive potassium
channels in this context, and iii) the homeostatic regulation of ATP levels upon neuronal
excitation and inhibition. In the second part, we aim to iv) give an overview on the
current knowledge how cerebral ATP levels and systemic metabolic processes interact
and v) explain the specific impact of this interaction on body weight regulation in a
physiologic and a pathologic state.
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