Inhibited TRHergic Pathway of Amygdala and Insular Cortex May Participate in High Anxiety Levels and Decreased Food Intake of Dehydrated-Induced Anorexic Rats (pp. 67-84)
Authors: (Patricia de Gortari, Elena Alvarez-Salas, Lorraine Jaimes-Hoy, Neurofisiología Molecular, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente, Tlalpan, México, and others)
Abstract: Thyrotropin-releasing hormone (TRH), a tripeptide synthesized in the paraventricular nucleus (PVN) of the hypothalamus and in other brain regions, is proposed with neuromodulatory functions implicated in anorexic and anxiolytic effects. Female rats, subjected to the dehydration-induced anorexia model (DIA) (drinking 2.5% NaCl solution for 7 days), present increased proTRH expression in anterior part of the PVN and inhibition of food intake, when compared to controls drinking tap water or to a pair-fed group (forced-food restricted, FFR), which eats the exact amount of food than DIA rats. DIA animals avoid food in spite of their weight loss probably due to the sensorial attributes of the NaCl solution. Thus, we evaluated here the activity of the TRHergic pathway in the insular cortex (IC), involved in the perception of the sensorial characteristics of food to define whether TRH in this region is altered and perhaps participates in the inhibited feeding of DIA rats.
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