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Changes in Appetite-Associated Hormone and Feeding Behavior in Advanced Age: Suggestions from Basic Research (pp. 157-170) $100.00
Authors:  (Tomohisa Hattori, Hiroshi Takeda, Tsumura and Co, Tsumura Research Laboratories, Japan)
Abstract:
Aging influences feeding behavior and was previously considered to be a metabolic change caused by decreased energy expenditure. However, as many mechanisms controlling feeding behavior have been elucidated, it has become evident that an age-related failure of the peripheral and central orexigenic systems plays a major role in decreased food intake. As a decline in food intake in cachexia associated with the aging process largely reflects future mortality rates, the necessity of controlling food intake in the elderly has been increasingly prioritized. Our research has revealed abnormalities in the secretion and function of ghrelin, an orexigenic hormone, and leptin, an anorexigenic hormone, in aged mice. These abnormalities are characterized by the reduction in ghrelin secretion under fasting conditions, resistance to ghrelin signals, and substantial increase in the plasma leptin levels in young mice maintained by feeding conditions. These peripheral appetite-associated hormones generally transmit signals to the paraventricular nucleus by modifying the activities of orexigenic neuropeptide Y/agouti-related protein (NPY/AgRP) neurons and anorexigenic proopiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus. Aged mice, however, neither display an increase in NPY/AgRP gene expression that is expected during fasting nor a decrease in POMC mRNA expression that occurs in young mice.
This chapter focuses on the functional and qualitative changes in appetite-associated hormones by aging. 


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Changes in Appetite-Associated Hormone and Feeding Behavior in Advanced Age: Suggestions from Basic Research (pp. 157-170)