Osteoporosis: Potent Treatment with Combination of Functional Food Factors (pp. 1-60)
Authors: (Masayoshi Yamaguchi, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA)
Abstract: Bone homeostasis is maintained through a delicate balance between osteoblastic bone formation and osteoclastic bone resorption. Osteoporosis is metabolic disorder, which is induced with its accompanying decrease in bone mass with increasing age and postmenopause. Decrease in bone mass causes bone fracture. Osteoporosis is widely recognized as a major public heath problem. Bone loss may be due to decreased osteoblastic bone formation and increased osteoclastic bone resorption. There is growing evidence that nutritional and food factors may play a part in the prevention of bone loss with aging and have been to be worthy of notice in the treatment of osteoporsis. Zinc, an essential trace element, genistein, an isoflavone which are largely contained in soybeans, menaquinone-7, a kind of vitamin K2 which is richly contained in fermentated soybean, and β-cryptoxanthin, a carotenoid which is greatly present in Satsuma mandarin orange, has been shown to have a stimulatory effect on osteoblastic bone formation and an inhibitory effect on osteoclastic bone resorption, thereby increasing bone mass. These factors have an effect on protein synthesis and gene expression, which are related to osteblastic bone formation and osteoclastic bone resorption. The combination of zinc and other each factor (including genistein, menaquinone-7, or β-cryptoxanthin) has been found to reveal the synergistic effect on bone. The oral administration with combination of zinc and other each factor has been shown to synergistically prevent on bone loss in ovariectomized rats, an animal model for osteoporosis, indicating a role in the treatment of osteoporosis. Moreover, the supplemental intake of ingrediant with the combination of zinc and other factors has been shown to have a potent effect on osteoporosis in human subjects. The combination of functional food factor may be a potent-useful tool in the prevention and treatment of osteoporosis.