Book Description:
Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Table of Contents:
Preface

Chapter 1. Organization of Neurotransmitter Receptors and Ion Channels on the Neuronal Surface; pp.-54
(Rafael Luj¨¢n, Univ. de Castilla-La Mancha, Spain)

Chapter 2. Type II MAGE Proteins at the Crossroads of Cell Death and Neurogenesis; pp. 55-74
(Jos¨¦ M. Frade, CSIC, Spain)

Chapter 3. The Activation of the S100A13/FGF1 Release Pathway: A Potential Mechanism of Tumor Progression in Human Brain Gliomas; pp. 75-85
(G. Di Leonardo, Catholic Univ., Italy, M. Landriscina, Univ. of Foggia, Italy and G. Schinzari et al., Catholic Univ., Italy)

Chapter 4. Response to Cadmium Stress by Neoplastic and Immortalized Human Breast Cells: Evidence for Different Modulation of Gene Expression; pp. 87-113
(Claudio Luparello, Rosalia Sirchia and Laura Paci et al., Univ. Palermo, Italy)

Chapter 5. MAPK Signalling Pathways as Targets for Gastrointestinal Cancer Therapy: From Laboratory to Clinical Trials; pp. 115-143
(Xia Wang and Jing Yuan Fang, Shanghai Jiaotong Univ. School of Medicine, China)

Chapter 6. Systems Biology and Systems Pharmacology of ¦Â2-Adrenergic Receptors in Human Epidermoid Carcinoma Cells; pp. 145-171
(Ye Fang, Ann M. Ferrie and Joydeep Lahiri, Corning Inc., USA)

Chapter 7. Targeting the P13K/PDK/Akt Signalling Pathway in Anticancer Therapy; pp. 173-190
(Paul W. Sylvester, Univ. of Louisiana at Monroe, USA)

Chapter 8. FLT3 Signal Transduction and Leukemia; pp. 191-204 (Shinichiro Takahashi, Tohoku Univ. Graduate School of Medicine, Japan)

Chapter 9. Peroxynitrite Signalling: A Target for Therapy in Inflammation; pp. 205-238
(J¨¢nos G. Filep, Driss El Kebir and Tarek Kreiss et al., Univ. of Montreal, Canada)

Index