Book Description:
Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer´s disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book presents new and exciting research in this related field.

Table of Contents:
Chapter Availability

Individual chapters are available for $25 each by sending an email to novascience@earthlink.net. Nova will provide the chapter for your easy downloading or send it as an email attachment if you prefer.

Preface

Chapter I.- The Role of BH3-only Proteins in Cancer and Anti-Cancer Therpeutics; pp. 1-39
(Junya Kuroda and Shinya Kimura, Kyoto Univ., Japan)


Chapter II.- Tumor Resistance to Cell Death and its Relationship with Protein Prion; pp. 41-91
(Maryam Mehrpour, Franck Meslin and Ahmed Hamai, Institut Gustave Roussy, France)


Chapter III.- Pancratistatin a Novel Highly Selective Anti-Cancer Agent that Induces Apoptosis by the Activation of Membrane-Fas-Receptor Associated Caspase-3; pp. 93-109
(Carly Griffin, Univ. of Windsor, Canada, James McNulty, McMaster Univ., Canada, Caroline Hamm, Windsor Regional Cancer Center, Canada, and Siyaram Pandey)


Chapter IV.- Neuropeptides as Modulators of Apoptosis in Prostate Cancer; pp. 111-149
(Jose Vilches and Mercedes Salido, Univ. of Cadiz, Spain)


Chapter V.- The Role of IAP as a Novel Diagnostic and Therapeutic Target for Prostate Cancer; pp. 151-168
(Takeo Nomura and Hiromitsu Mimata, Oita Univ., Japan)


Chapter VI.- Different Response of Normal and Cancer Human Colon Epithelial Cells to Dietary Fatty Acids and Endogeneous Apoptotic Regulators of the TNF Family; pp. 169-206
(Jiøina Hofmanová, Alena Vaculová and Martin Hýžd'alová, Academy of Sciences of the Czech Republic, Czech Republic)


Chapter VII.- Targeting Cell Cycle in a Coordinated Strategy for Anticancer Treatment and Neuroprotection; pp. 207-230
(Vilen A. Movsesyan and Alexander G. Yakovlev, Georgetown Univ., USA)


Chapter VIII.- Modulating Apoptosis Thresholds in Cancer Therapy; pp. 231-244
(Christoph Herold and Matthias Ocker, Univ. Hospital Erlangen, Germany)


Chapter IX.- Effects of Pegfilgrastim Administration on Neutrophil Apoptosis in Breast Cancer Patients Treated with Dose-Dense Chemotherapy Regimens; pp. 245-261
(Rosangela Invernizzi, Donatella Grasso and Erica Travaglino et al., Univ. of Pavia, Italy)


Chapter X.- Rapamycin Controls Multiple Signalling Pathways Involved in Cancer Cell Survival; pp. 263-276
(Maria F. Romano, Simona Romano and Maria Mallardo et al., Univ. Federico II, Italy)


Index