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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.Myelin Basic Protein
05.New Research on Genomic Instability
06.Developmental Gene Expression Regulation
07.Lecture Notes on Computational Mutation
08.Fragile Sites: New Discoveries and Changing Perspectives
09.Progress in Stem Cell Applications
10.Genetic Vectors Research Focus
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Fragile Sites: New Discoveries and Changing Perspectives
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Editors: Isabel Arrieta (Univ. del Pais Vasco, Bilbao, Spain), Olga Penagarikano, Mercedes TÚlez
Book Description:
Fragile sites common features of human (and also of other mammalian) chromosomes. Chromosomal fragile sites are non-randomly distributed loci that are especially prone to forming gaps, breaks or triradial figures in metaphase chromosomes when cells are cultured under conditions that inhibit DNA replication or repair. This new and important book is divided into 3 parts: 1. An overview about fragile sites on chromosomes, their classification, cytogenetics, expression, replication timing, and clinical significance and heritance, 2. The characteristics of fragile loci which lead to the expression of fragility specifically at these sites and 3. the link between fragile sites and human pathological conditions.

Table of Contents:
Chapter Availability

Individual chapters are available for $25 each by sending an email to Nova will provide the chapter for your easy downloading or send it as an email attachment if you prefer.





Chapter I.- Fragile Sites on Human Chromosomes; pp. 3-17
(By Grant R. Sutherland)

II. Basis For The Expression of Fragile Site

Chapter II.- Molecular Basis for Expression of Common and Rare Fragile Sites in the Human Genome; pp. 21-43
(By Michal Schwartz, Eitan Zlotorynski and Batsheva Kerem)

II.1. DNA Replication

Chapter III.- Common Fragile Sites: Cytogenetics and Cell Cycle Checkpoints; pp. 47-66
(By Anne M. Casper, Martin F. Arlt and Thomas W. Glover)

Chapter IV.- The Implications of DNA Replication in Common Fragile Site Expression; pp. 67-98
(By Isabelle Lucas, Aparna Palakodeti and Michelle M. Le Beau)

Chapter V.- A Common Replication Pattern Underlies the Fragility at Fragile Site Regions; pp. 99-115
(By Ayelet Rahat, Asaf Hellman and Batsheva Kerem)

II.2. DNA Packaging

Chapter VI.- Role of DNA Packaging on Rare Fragile Site Expression; pp. 119-146
(By Cristina Morelli, Mauro Tognon and Giuseppe Barbanti-Brodano)

Chapter VII.- Nucleosome Assembly on DNA Derived from Rare Fragile Sites; pp. 147-165
(By Yuh-Hwa Wang)

Chapter VIII.- AT-Islands in Fragile Sites as Scaffold / Matrix - Attachment Regions (S /MARs); pp. 167-190
(By Jan M. Woynarowski)


Chapter IX.- Common Fragile Site Genes; pp. 193-222
(By David I Smith, Sarah McAvoy and Fang Wang)

Chapter X.- Fragile Genes at Common Chromosomal Fragile Sites: Roles in Carcinogenesis; pp. 223-239
(By Gulnur Guler, Dimitrios Iliopoulos, Shuang-Yin Han, and Teresa Druck, et al)

Chapter XI.- WWOX, The Target of Common Chromosomal Fragile Site, FRA16D, is Frequently Dysregulated in Multiple Tumor Types;
pp. 241-260
(By John H. Ludes-Meyers, Maria Inez Nunez and C. Marcelo Aldaz)

Chapter XII.- Peptide Encoded by an Intron of the Putative Tumor Suppressor Gene Testin of the Common Fragile Site 7G is a Cancer Antigen Recognized by Citotoxic T Lymphocytes; pp. 261-270
(By Akira Yamada and Kyogo Itoh)


Chapter XIII.- FRA11B and Jacobsen Syndrome; pp. 273-282
(By Christopher Jones and Paul Grossfeld)

Chapter IXV.- FRAXA / Fragile X Syndrome; pp. 283-298
(By Olga Penagarikano and Stephen T. Warren)

Chapter XV.- FMR1 Premutation: A Leading Cause of Inherited Ovarian Dysfunction; pp. 299-320
(By Stephanie L. Sherman, Kira Taylor and Emily G. Allen)

Chapter XVI.- New Developments in Fragile X - Associated Tremor / Ataxia Syndrome (FXTAS); pp. 321-343
(By Flora Tassone, Sarah Coffey and Randi J. Hagerman)


   Binding: Hardcover
   Pub. Date: 2007
   ISBN: 1-60021-504-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Fragile Sites: New Discoveries and Changing Perspectives