Pharmacokinetics and pharmacodynamics and adolescence (pp. 133-142)
Authors: Cynthia L Feucht and Dilip R Patel
Abstract: Clinicians can optimize pharmacotherapy within their patient population by having a solid understanding of the principles of pharmacokinetics and pharmacodynamics. Knowledge of these concepts can aide in the development of the dose and dosing interval, determine the optimal route, evaluate for significant interactions as well as understand other factors that influence drug response including age, genetics and comorbid disease states. Drug therapeutic monitoring may be a useful tool for some drugs to evaluate for efficacy but is not applicable to all medications. Genetics is playing a more predominant role as pharmacogenetics and pharmacogenomics evolves to optimize drug efficacy and minimize toxicity. The concepts of pharmacokinetics, pharmacodynamics, therapeutic drug monitoring and pharmacogenetics/pharmacogenomics are discussed in further detail in this paper.