Abstract: Participation of hippocampus in memory formation still remains one of the actual problem in neuroscience. People with injured and animals with operated hippocampus undergo full amnesia of learning that is complicated by the differences in physiological and biochemical variety of pyramidal neurons. It is well known, that synapses of pyramidal neurons of hippocampus are characterized high specific acetylcholinesterase (ACHE) activity that attracts peculiar interest to its role in the formation of memory (Kruglikov ). Majority of scientists point out those rats with a high ACHE activity in brain possess good memory and better ability to solve maze problems (Bennett et al. , Rosenzweig at al. , Rosenzweig et al. , Saunders , Pryor ). Correlation between cortex ACHE activity and number of predicted reactions at defensive reflexes has been demonstrated (Ivonin ).
Considering above mentioned we set as a goal to study the changes of ratsí ACHE activity in dynamics during learning to get food by non-preferred paw. ACHE activity had been studied in brain motor cortex (2.7 mm laterally and 1.6 mm rostrally from bregma) the damage of which causes full amnesia in learning to obtain food by non-preferred paw (Book , Peterson, Devine ) and in pyramidal neuros of CA3-4. For the study of biochemical correlates of memory we used enzyme ACHE as one of the neurochemical correlates of learning.