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01.Kinase Signalling and Cardiac Remodelling: A Review (pp. 29-64)
02.Therapeutic Effectiveness of Clopidogrel-Induced Platelets Inhibition: An Inter-Individual Response Variability among Iraqi Patients (pp. 23-28)
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Therapeutic Effectiveness of Clopidogrel-Induced Platelets Inhibition: An Inter-Individual Response Variability among Iraqi Patients (pp. 23-28) $50.00
Authors:  Hussein Ali Sahib, Bassim Irheim Mohammad, and Ban A. Abdul-Majid
Abstract:
Background: Despite the unmistakable beneficial effect of clopidogrel on platelet aggregation, some patients still respond poorly to the drug, leading to early and adverse cardiovascular clinical events.

Patients and methods: One hundred and twenty-seven patients with cardiovascular diseases (ACS, stroke, or TIA) were enrolled as a study group. Patients were recruited at the coronary care unit (CCU) of Al-Yarmouk Teaching Hospital. Platelet assessment was performed by using light transmission aggregometry.

Results: The mean value of platelet aggregation was 61.7+17.3; the median value was 64 and the range was 10-96. The range shows a considerable amount of variability. Types of variability can be referred to as either skewness or kurtosis. Skewness is a measure of the symmetry of a distribution. The data in Table 1 show that skewness was negative (-0.450), suggesting a deviation from the normal distribution. Kurtosis, a measure of the peakedness or flatness of a distribution, was also negative (-0.130), suggesting a flat peak. Twenty four percent of the patients enrolled in this study were hypo-responders.

Conclusions: Among the patients enrolled in this study, there was significant (p<0.05) inter-individual variability with negative skewness and kurtosis (-0.450, -0.130, respectively). 


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Therapeutic Effectiveness of Clopidogrel-Induced Platelets Inhibition: An Inter-Individual Response Variability among Iraqi Patients (pp. 23-28)