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Coumarin Anticoagulant Research Progress
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Editors: Joseph P. Edardes
Book Description:
Warfarin (also known under the brand names of Coumadin, Jantoven, Marevan, and Waran) is an anticoagulant medication that is administered orally or, very rarely, by injection. It is used for the prophylaxis of thrombosis and embolism in many disorders. Its activity has to be monitored by frequent blood testing for the international normalized ratio (INR). It is named for the Wisconsin Alumni Research Foundation.

Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in licorice, lavender and various other species. Warfarin was originally developed as a rat poison; however, more modern poisons are much more potent and toxic (e.g., brodifacoum). Warfarin and contemporary rodenticides belong to the same class of drugs (coumarins) and both decrease blood coagulation by interfering with vitamin K metabolism. For this reason, drugs in this class are also referred to as vitamin K antagonists.

Table of Contents:
Preface

Expert Commentary

Commentary A - Emergency Warfarin Reversal, pp. 1-9;
(Michael Levine and Joshua N. Goldstein)

Research and Review Articles

Chapter 1 - Coumarin Anticoagulants & Endocrine Interactions,
pp. 11-45;
(Paul Grant)

Chapter 2 - Factors Affecting Anticoagulation Response to Warfarin, pp. 47-77;
(Elizabeth A. Sconce, Hilary A. Wynne and Farhad Kamali)

Chapter 3 - Warfarin: New Approaches to Improve Safety, pp. 79-98;
(Sam Schulman and Julia Anderson)

Chapter 4 - Mechanism of Antitumor Effects of Simple Coumarins in Murine Melanoma and Human Non-Small Cell Lung Carcinoma Cell Lines, pp. 99-112;
(Jose Sullivan Lopez-Gonzalez, Heriberto Prado-Garcia, Patricia Rosas-Medina, Nicandro Mendoza-Patiño, Juan J. Mandoki and Juan A. Molina-Guarneros)

Chapter 5 - Coumarin Intoxication, pp. 113-122;
(Viroj Wiwanitkit)

Chapter 6 - Coumarin and 70H-Coumarin as Anti-carcinogenic Agents. Inhibition of the K-ras Oncogene in Human Lung Cancer, pp. 123-135;
(Carmen Martha Elinos-Báez)

Chapter 7 - Genetic Polymorphism and Courmarin Metabolism,
pp. 137-146;
(Viroj Wiwanitkit)

Index

   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 1-60021-990-X
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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