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04.Tumor Budding in Colorectal Cancer: Recent Progress in Colorectal Cancer Research (Horizons in Cancer Research, Volume 8)
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10.Therapeutic Perspectives of Gastrointestinal Melatonin (pp. 233-252)
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Sleep Effect on Gastrointestinal Health and Disease: Translational Opportunities for Promoting Health and Optimizing Disease Management
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Editors: David A. Johnson, M.D., William C. Orr, Ph.D., J. Catesby Ware, Ph.D., Parth Parekh, M.D. and Edward C. Oldfield IV, M.D. (Eastern VA Medical School, Norfolk, VA, USA)
Book Description:
Sleep disorders are abnormal sleep patterns and physiological changes that affect health. Over one third of Americans experience chronic sleep disturbance which contributes to numerous health conditions including: Cardiovascular and respiratory disease, depression, chronic pain syndromes, gastrointestinal diseases and decreased quality of life, among others. Chronic sleep deprivation is an epidemic that can have cumulative neurocognitive effects and exacerbate a broad array of common chronic diseases including obesity, hypertension, diabetes, stroke and coronary artery disease.

The effect on gastrointestinal health and disease is profound, albeit typically not recognized or addressed by clinicians. Dysfunctional sleep has been identified in a wide array of GI diseases affecting both visceral and hepatic disease, with both inflammatory and neoplastic induction.

Sleep and the GI system have a dynamic bidirectional relationship, effecting a complex balance of circadian rhythms, neurohumoral transmitters and the intestinal microbiome. The resultant effects of this interplay between sleep and GI health/disease is often difficult to define, however, a primary sleep disorder may be exacerbated by a GI disease, such as GERD, or a GI disease such as IBD may be the primary underlying cause of a sleep disorder. Regardless, there is emerging recognition that sleep and GI health may represent new targets for disease intervention. This includes the identification of genomic changes where gene products may be potential therapeutic targets. Additionally, epigenetic changes related to the environment can enhance the transcriptional activity of important genes. Also, clearly the intestinal microbiome is a discovery field for microbial products and activated immune cells that may translocate to the periphery and respond to manipulation. This relationship with sleep is another new horizon of recognition.

As these relationships between sleep and GI health have been identified, these findings are logical targets for intervention. As such, a keen and insightful awareness is necessary to maintain good health, or assessing symptoms of a disease state. Thus, the recognition of sleep disorders, and appropriate sleep directed management can help optimize the treatment of numerous gastrointestinal diseases.

Clearly, people need to recognize that sleep is not just a “placeholder” of dark time between two periods of daylight activity. Rather, assessing and promoting good sleep should be a “health mandate” for maintaining and regulating normal GI physiologic health, or mitigating sleep directed disease management strategies to optimize patient outcomes. Therefore, sleep dysfunction, should be a routine focus of all care providers, recognizing the importance of good sleep for promoting health and sleep disorders in perpetuating disease.
It is the meaningful intent of the authors of this treatise to increase the appropriate awareness of the invaluable role of sleep. Clearly, it is time for us all to open our eyes and realize the value of closing them. (Nova Biomedical)

J. Catesby Ware PhD FAASM
Parth Parekh MD
Edward C. Oldfield IV MD
William Orr PhD FACG

Table of Contents:

Chapter 1. Physiologic Regulation of Sleep and Health (pp. 1-16)
(J. Catesby Ware)

Chapter 2. Sleep, Immune Function, and the Gut Microbiome: Pathophysiologic Translational Implications (pp. 17-40)
(Larry D. Sanford and Richard P. Ciavarra)

Chapter 3. Sleep and Circadian Rhythms: Implications for Gastrointestinal Health (pp. 41-66)
(Christopher B. Forsyth, Robin M. Voigt, Faraz Bishehsari, Garth R Swanson, Heather Rasmussen and Ali Keshavarzian)

Chapter 4. Sleep Dysfunction and Effects on the Gut Microbiome: Clinical Implications (pp. 67-94)
(Edward C. Oldfield IV, Maurice S. Marcuard, Will R. Takakura and David A. Johnson)

Chapter 5. Sleep Dysfunction: Definitions and Prevalence (pp. 95-108)
(Vishant Ramadorai and David A. Johnson)

Chapter 6. Assessment of Sleep in Clinical Practice (pp. 109-128)
(William C. Orr and Samih Raad)

Chapter 7. Sleep Dysfunction and Gastroesophageal Reflux Disease: Beyond Heartburn (pp. 129-158)
(Edward C. Oldfield IV, Ross C. D. Buerlein and David A. Johnson)

Chapter 8. Sleep, Autonomic Dysfunction and Irritable Bowel Syndrome (IBS) (pp. 159-176)
(Minjeong Christine Kwon and Eamonn M. M. Quigley)

Chapter 9. Sleep Dysfunction and Inflammatory Bowel Disease (pp. 177-200)
(M. Anthony Sofia, Michael Andersen and David T. Rubin)

Chapter 10. The Role of Sleep Dysfunction in the Pathogenesis of Obesity and Metabolic Disease (pp. 201-220)
Parth J. Parekh, Saamia Faruqui, Eric Montminy, Katherine Boland, and Luis A. Balart)

Chapter 11. Sleep Dysfunction and Liver Disease (pp. 221-236)
(Parth J. Parekh, Patrick Chang, Alex Sarkisian, Molly Delk Plummer and Luis A. Balart)

Chapter 12. Sleep Dysfunction in Gastrointestinal Malignancy (pp. 237-264)
(Jennifer Copare , Danielle M Pastor, Adebisi Alimi and David A. Johnson)

Chapter 13. Sleep, Critical Illness, and Gastrointestinal Disease: Exploring the Connection (pp. 265-280)
(Mit P. Patel, Joshua M. Sill, Edward C. Oldfield IV and David A. Johnson)

Chapter 14. Good Sleep and Good Health (pp. 281-290)
(Kellie R. Jones and William C. Orr)

Chapter 15. Non-Pharmaceutical Therapies for Sleep Dysfunction and Gastrointestinal Health (pp. 291-314)
(Skye Ochsner Margolies and John L. Schwartz)

Index (pp. 315)

Total Pages: 323

      Sleep - Physiology, Functions, Dreaming and Disorders
   Binding: Hardcover
   Pub. Date: 2018 - March
   ISBN: 978-1-53613-359-2
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Sleep Effect on Gastrointestinal Health and Disease: Translational Opportunities for Promoting Health and Optimizing Disease Management