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Inhaled Anesthetic Potency Results from Charge Delocalization and Stability of a Charge Transfer Complex at an Electron-Transfer Site in Microtubules: A Unitary Theory of General Anesthesia (pp. 199-243) $0.00
Authors:  Barry R. Duncan and Joel F. Liebman
Abstract:
A reaction mechanism is developed for a unitary theory of general anesthesia. Anesthetic potency, which can now be predicted/explained from chemical structure, results from the stabilization of a charge transfer complex at an electron-transfer/proton-transfer site causing a decrease in ET rate. All anesthetics will ultimately interact with the same site by acting as charge acceptors. Convulsive effects result from increasing the ET rate. The state of consciousness is a balance between these two variances and is maintained when O2, the normal electron acceptor, reacts without interference. This suggests a reason for the rapid (6 seconds or less) loss of consciousness due to anoxia. The effects of tubulin GTP hydrolysis in microtubules on kinesin suggest a route to the inhibition of SV transport to the RRP and vesicle fusion, decreasing synaptic transmission. 


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Inhaled Anesthetic Potency Results from Charge Delocalization and Stability of a Charge Transfer Complex at an Electron-Transfer Site in Microtubules: A Unitary Theory of General Anesthesia (pp. 199-243)