Oral Mucositis: Prevention and Treatment (pp. 7-15)
Authors: Héliton Spindola Antunes, Paulo Sérgio da Silva Santos, Fábio Luiz Coracin, Geisa Badauy Lauria Silva, Luiz Antonio de Souza, and Luiz Alberto Soares Valente Jr.
Abstract: Oral Mucositis (OM) is one of the main complications of patients submitted to the oncologic treatment. The incidence of oral mucositis varies, and is intimately related to the toxicity of chemotherapy and radiotherapy protocol. Prolonged or profound oral mucositis leads to significant pain and morbidity and depending on its progression, it may be necessary to interrupt the treatment followed or not by hospitalization.
OM occurs approximately in seven to ten days after chemotherapy and from the second week of radiotherapy. Although it is a toxic reaction and inflammation that is studied for a long time, the molecular and cell mechanisms described recently may contribute for the appearance of new protocols of prevention. In the context of options studied in the prevention of OM, there are efficient alternatives as cryotherapy, growth factor of keratinocytes and the low-level lasers that promote a reduction in the incidence of OM and pain during the period of the oncologic treatment.
The aim of this chapter was to investigate the available literature regarding OM, searching relevant articles and eligible clinical trials in order to obtain additional information about prevention and treatment interventions to OM.