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Temporal Lobe Epilepsy: Pathologic Substrates and Causes
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Editors: Richard A. Prayson, M.D. (Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Department of Anatomic Pathology, Cleveland, OH, US)
Book Description:
Pharmacoresistent or medically intractable epilepsy remains a challenge for those who are involved with the care of patients who suffer from this problem. Many of these patients have epilepsy originating in the temporal lobe. Surgical intervention still remains a therapeutic option for many of these individuals with variable success rates. The focus of this text is to review some of the underlying pathologic findings encountered in patients with medically intractable epilepsy who undergo the surgical resection of the epileptogenic focus. The research efforts in this arena have been considerable in recent years and have resulted in classification schemas of entities such as focal cortical dysplasia, hippocampal sclerosis and brain tumors that are being employed internationally. The chapters in this text explore in some detail some of the more commonly encountered pathologic findings in tissues resected in this population of patients. A review of current classification schemas and some of the limitations associated with such schemas are explored. Among the topics that will specifically be examined in this text are the more commonly encountered etiologies including hippocampal sclerosis, the focal cortical dysplasias as well as other developmental anomalies, glioneuronal tumors and vascular lesions. (Nova)

Table of Contents:

Chapter 1. The Histopathologic Patterns of Focal Cortical Dysplasia in the Temporal Lobe
(Robert J. Marquardt and Richard A. Prayson, MD, Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH, US and others)

Chapter 2. The Pathologic Spectrum of Hippocampal Sclerosis
(Jordan M. Gales, MD, and Richard A. Prayson,MD, Duke University Medical Center, Department of Medicine, Durham, North Carolina, US, and others)

Chapter 3. Glioneuronal Tumors in Temporal Lobe Epilepsy: Molecular and Genetic Considerations
(Carol Swetlik and Richard Prayson, MD, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Department of Anatomic Pathology, Cleveland, OH, US)

Chapter 4. Vascular-Related Pathologic Substrates of Temporal Lobe Epilepsy
(Akshay Sharma, MD, and Richard A. Prayson, MD, Case Western Reserve University School of Medicine and Cleveland Clinic, Cleveland, Ohio, US)


      Neuroscience Research Progress
   Binding: Softcover
   Pub. Date: 2018 - December
   ISBN: 978-1-53614-409-3
   Status: AP
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Temporal Lobe Epilepsy: Pathologic Substrates and Causes