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Impact of Oxidative Stress on Diabetes Mellitus and Inflammatory Bowel Diseases
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Authors: Jana Varvařovská, Josef Sýkora, Zdeněk Rušavý, Jaroslav Racek, Silva Lacigová, Konrad Siala (Charles University Prague, and University Hospital Plzen, Czech Republic) and Rudolf Štětina (University of Defence Brno, Czech Republic) 
Book Description:
Formation of reactive oxygen species (ROS) is a natural process during oxidative metabolism. ROS play an important role not only in pathological processes of human organism as usually presented but less attention is paid to their proper important role in cell signaling, biosynthesis or non-specific antiinfectious defence. Overproduction of ROS during numerous pathological situations in presence of insufficient antioxidant protection leads to substantial oxidative changes of lipids, proteins, sugars, and also DNA. Protection against ROS is assured by different extracellular or intracellular antioxidant mechanisms as studied during last decades. Antioxidant enzymes rectifying the oxidative damage are studied with regard to their different activities and usefulness in body protection. Their genetic polymorphisms are certainly involved in different response to oxidative stress.

Special attention should be devoted to the topic of oxidative nuclear and mitochondrial DNA damage and its restoring via DNA repair process, especially base excision repair (BER). A large scale of antioxidant enzymes is involved in correction of DNA oxidative damage. Natural trend of worsened DNA repair is usually associated with aging. Other pathologies related with deficient DNA repair are susceptibility to carcinogenesis (lack of apoptosis control) or degenerative diseases.

Oxidative stress is involved in the pathophysiology of diabetes mellitus (DM – oxidative stress of mainly metabolic origin) and inflammatory bowel diseases (IBD – oxidative stress of mainly inflammatory origin). In spite of confirmed OS in DM or IBD, the substantial information about the intensity of DNA repair and its possible relationship to the disease course and development of chronic complications is missing.

The author pilot studies completed both in adult and pediatric patients with DM or IBD confirmed an increased oxidative stress as well as oxidative DNA damage examined with comet assay. The surprising findings were ascertained in intensity of DNA repair (analysed with modified comet assay).

Table of Contents:
Preface
Introduction
DNA Oxidative Damage and DNA Repair
Oxidative Stress and Pathophysiology of Diabetes Mellitus and Inflammatory Bowel Diseases
Examining Oxidative Stress,DNA Damage and DNA Repair in Patients with Diabetes Mellitus and Crohn Disease
References
Index

   Binding: Softcover
   Pub. Date: 2008 1st Quarter
   ISBN: 978-1-60456-152-4
   Status: AP
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Impact of Oxidative Stress on Diabetes Mellitus and Inflammatory Bowel Diseases