Book Description:
When used in the context of reproduction of living cells the phrase "cell growth" is shorthand for the idea of "growth in cell populations by means of cell reproduction." During cell reproduction one cell (the "mother" cell) divides to produce two daughter cells.
Cell proliferation, which depends on the intimately linked processes of growth and division, is a fundamental systems-level attribute of all life forms. The precise regulation of proliferation in response to internal and external cues is critical for development, tissue renewal and evolutionary fitness, while the disregulation of cell proliferation underlies a variety of human diseases, most notably cancer and aging. Historically, breakthroughs in our understanding of cell growth and division have derived from cross-fertilization of results and ideas from researchers studying a wide range of model organisms, from yeast to humans. The basis for cell proliferation entails the control of key signaling and cell cycle regulators through transcriptional, translational, post-translational, genetic and epigenetic mechanisms. Indeed, many conceptual breakthroughs in cell regulation have derived from analyses of basic cell cycle mechanisms. This new book presents the latest research in the field.

Table of Contents:
Preface

Expert Commentary

Cell Growth Measurement and Kinetic Parameters in Cutaneous Melannoma: is MIB-1 Index an Useful Indicator to Predict Patients Ootcome?; pp. 1-3
(Vereecken Pierre, Laporte Marianne, Petein Michel, Departments of Dermatology, CHU-Brugmann/Institut Jules Bordet, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Belgium)

Research and Review Studies

Chapter I - Cell Colonization Control by Physical and Chemical Modification of Materials; pp. 5-56
(L.Bačáková, Department of Growth and Differentiation of Cell Populations, Institute of Physiology, Academy of Sciences of the Czech Republic, V. Švorčík, Department of Solid State Engineering, Institute of Chemical Technology, Czech Republic)

Chapter II - The Contribution of Cellular Proliferation in the Skeletal Muscle Regenerative Response; pp. 57-88
(Rita Ferreira, CIAFEL, University of Porto, University of Aveiro, ESSVA Health School, Portugal, Maria João Neuparth, CIAFEL, University of Porto, ESSVA Health School, Portugal, Rui Vitorino, CIAFEL, University of Porto, University of Aveiro, Portugal)

Chapter III - On the Biological Significance of Tumor Growth;
pp. 89-121
(Raúl A. Ruggiero, Oscar D. Bustuoabad, Paula Chiarella, División Medicina Experimental, Instituto de Investigaciones Hematológicas, Argentina)

Chapter IV - Implication of Asymmetric Dimethylarginine (ADMA) in Endothelial Cell Growth Process in Atherosclerosis; pp. 123-137
(Seiji Ueda, Kei Fukami, Sho-ichi Yamagishi, Department of Medicine, Kurume University School of Medicine, Japan)

Chapter V - Epidermal Growth Factor Receptor Dependent Mitogenic Signaling in Normal and Malignant Mammary Epithelial Cells;
pp. 139-157
(Paul W. Sylvester, Sunitha V. Bachawal, Vikram B. Wali, College of Pharmacy, University of Louisiana at Monroe, USA)

Chapter VI - Regulation of Endothelial Cell Proliferation by Estrogen in Reproductive Organs; pp. 159-182
(Keiichi Matsubara, Yuko Matsubara, Emiko Abe, Department of Obstetrics and Gynecology, Ehime University School of Medicine, Japan)

Chapter VII - Influence of Rapid Prototyped Scaffolds’ Pore Volume and Shape on Cartilage Regeneration; pp. 183-201
(Lorenzo Moroni, Joost R. de Wijn, Clemens A. van Blitterswijk, Institute for Biomedical Technology, University of Twente, The Netherlands)

Chapter VIII - Transcriptional Regulation of Neurotrophic Factor in the Process of Neurite Growth; pp. 203-217
(Seyeon Park, Department of Applied Chemistry, Dongduk Women’s University, Korea)

Index