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Circadian Dysfunction in Fibromyalgia Rheumatica (pp. 43-45) $0.00
Authors:  Ghizal Fatima and Ram B. Singh
Abstract:
Circadian rhythms are 24-hour cycles that are part of the body’s internal clock, running in the body to carry out essential functions and processes. Fibromyalgia syndrome (FMS) is often triggered by a stressful event that includes physical stress or emotional stress. Possible triggers for FMS include: a viral infection, an injury. FMS is a chronic disease of unknown etiology, characterized by musculoskeletal pain. FMS is associated with multiple symptoms, including malaise, myalgia, insomnia, exhaustion, gastrointestinal symptoms, and loss or decline in memory function (Figure 1).
A reciprocal relationship between sleep and pain in FMS that can lead to significant deregulation of behavioral patterns in activity and sleep-wake schedules, and to avoidance behaviors that may suppress an effective coping response to worsened pain, fatigue, mood, and sleep. It is common among those whose regional time zone and sleep-wake cycle are aberrantly oriented with a circadian pacemaker in the hypothalamus. Circadian disruption may therefore lead to disruption in the release of hormones especially cortisol and melatonin. The circadian pacemaker in the brain has been reported to be disturbed in women with FMS. The circadian pacemaker located in brain influences the secretion of melatonin hormone and pursuits of the hypothalamic-pituitary-adrenal axis (HPA). Disruptions have been reported in both these systems in FMS. This review examines the evidence on the role of sleep and circadian rhythm disruptions, regarding new therapeutic concepts in FMS patients. 


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Circadian Dysfunction in Fibromyalgia Rheumatica (pp. 43-45)