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Efficacy and Safety of Chrono-Modulated Statin Therapy as Modified Method of Treatment of Hypercholesterolemia (pp. 81-83) $0.00
Authors:  Andrea Laurentius
Abstract:
Hypercholesterolemia increases the risk of cardiovascular diseases, and is a leading cause of global mortality. Based on the American Heart Association guideline, statin is indicated for patients with a family history of cardiovascular diseases and low-density lipoprotein (LDL) cholesterol higher than 160 mg/dL. Statins are administered once daily, yet no guideline has specified their intake time. It is important to evaluate the chronotherapeutic effect of statins toward hypercholesterolemia because the bioactivity of the drug may vary according to time structure [1]. This review aims to highlight the role of chronotherapy with statins to emphasize its enhanced chrono-pharmacokinetics and chrono-bioactivity, as well as safety. 


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Efficacy and Safety of Chrono-Modulated Statin Therapy as Modified Method of Treatment of Hypercholesterolemia (pp. 81-83)