The Evolution of Circadian Rhythm and Increased Oxidative Stress as Mechanisms of Circadian Dysfunction (pp. 85-87)
Authors: Richa H. Rai, Ram B. Singh, Sergey Chibisov, O. A. Bawareed, Elena Kharlitskaya, and Monica Jain
Abstract: Homo erectus ventured to the river banks or water reservoirs in the woods and forest early in the morning for hunting animals as they made an appearance from the thick woods to drink water. This activity was very exhaustive and associated with marked physical exertion and mental stress with underlying increased adrenergic activity and bio-chemical storm of increase in catecholamines, and cortisol with low release of acetylecholine. The present viewpoint aims to discuss the proposed causes in the pathogenesis of the evolution of circadian dysfunction in the morning.
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