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Chronobiogical Aspects of the Influence of Iodine Deficiency on the State of Periodontal Tissues and Mucosa (pp. 125-128) $0.00
Authors:  T. I. Ganeev, M. F. Kabirova, F. Kh. Kamilov, E. R. Farshatova, N. V. Kudashkina, L. P. Gerasimova, and M. V. Galiullina
Abstract:
Epidemiological studies of dental diseases carried out in many countries of the world indicate significant differences in the prevalence and intensity of dental caries, periodontal and oral mucosa diseases, and the possible role of iodine in the development of these processes [1-4]. Iodine deficiency disorders may be an underlying mechanism to explain the rapid emergence of non-communicable diseases, which may be associated with decline in immunity, thyroid disorders and circadian dysfunction [3-5]. More than 50% of the territory of Russia is iodine-deficient and about 100 million people live in these regions in a state of chronic insufficiency. Iodine deficiency manifests in a variety of pathologies, from defects in physical and intellectual development, reproductive disorders, to specific diseases of the thyroid gland as well as decline in the immunity [1-4]. According to epidemiological surveys, the prevalence of endemic goiter in Russia in children and adolescents is 15-25%, and in some regions, it is up to 40% [2]. The median of ioduria averages 82.2 μg/L (norm 150-250 μg/L) with fluctuations in individual regions from 17 to 125 μg/L. There is evidence that thyroid hormones (precursor thyroxine T4 and active T3) are iodine containing compounds (iodothyronines) that are important for metabolism, heat production, proper development and differentiation of cells, and growth [5]. The circadian clock, via the suprachiasmatic nucleus pacemaker, has a significant influence on the hypothalamic–pituitary–thyroid axis, which may be under the influence of iodine deficiency-induced thyroid disorders [5]. This review aims to provide a brief description of chronobiological aspects of these conditions as well as the role of iodine deficiency in the pathogenesis of oral cavity diseases. 


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Chronobiogical Aspects of the Influence of Iodine Deficiency on the State of Periodontal Tissues and Mucosa (pp. 125-128)