Chronobiological Processes of Free Radical Oxidation of the Oral Fluid and Oral Candidiasis (pp. 129-132)
Authors: A. R. Sultanshina, M. F. Kabirova, L. P. Gerasimova, T. S. Chemikosova, A. A. Golub, and L. I. Kuznecova
Abstract: Chronic inflammatory diseases of various etiologies are associated with activation of free radical oxidation (FRO) processes [1-3]. An important role in this process is played by the activation of phagocytic cells that produce reactive oxygen species in excess, which leads to further progression of the pathological process. The amount of free radicals and the rate of FRO in tissues and organs change significantly under the influence of unfavorable factors, stress and in various diseases, including inflammatory ones. Endotoxin and other waste products of a microbial cell as well as fragments of destroyed cells stimulate an inflammatory response activating polymorphonuclear leukocytes with the release of free radicals [1, 3]. Despite some features of the course of inflammation in various organs and tissues, the participation of reactive oxygen species in the development of an infectious-inflammatory process is a universal response of the body . Candidiasis of the oral mucosa is caused by fungi of the genus Candida belonging to the opportunistic microflora [3-6]. When they multiply, lytic enzymes are formed such as proteinases, phospholipases, hemolytic factor. This increases the resistance of the fungal cell to the body’s defense mechanisms [1-5]. Thus, candidiasis is mainly caused by the weakening of the resistance of the human body due to chronic diseases, such as diabetes and drug therapy. There is an unmet need to take into account the state of the FRO of the oral fluid when choosing the means and methods of treating candidiasis. The goal of the research was to study mechanisms of FRO of the oral fluid in patients with oral candidiasis in subjects with diabetes mellitus and those on drug therapy for other diseases.
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