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Cardiocerebral Effects on the Temporal Organization of Blood Pressure in Patients with Multiple Sclerosis Living in the North (pp. 141-143) $0.00
Authors:  Zh. I. Molchanova, O. N. Ragozin, and Omar Al-Bawareed
Abstract:
The etiology, pathogenesis, and clinical patterns of multiple sclerosis (MS), as well as the degree of involvement of other body systems in disease progression, have been studied for many years [1, 2]. The pathogenesis of comorbid cardiovascular compl-ication worsens the course and prognosis of MS, and the possible involvement of a vascular factor in the pathogenesis of MS, confirmed by neuroimaging. According to neuroimaging of the brain in older patients, more than 45 years, with a history of vascular disease, in addition to demyelination, focal microcirculation disorders are also detected, similar to changes in patients with cerebrovascular diseases [1, 2]. Organic damage to the descending autonomic pathways in the brain stem and spinal cord may lead to deteriorations of the functions of the autonomous nervous system, such as a decrease in heart rate variability [1, 2]. Chronic stress associated with this pathology leads to hyperreactivity of the hypo-thalamic-pituitary-adrenal axis, which predisposes to an increase in blood pressure (BP). Medications used in recent decades that change the course of MS can also have adverse effects associated with the cardio-vascular system. There is evidence from the Northern region that cardiovascular diseases (CVDs) occur at an earlier age and have a high prevalence among people of working age. This study aims to examine the temporal organization of BP in MS patients living in the Northern region. 


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Cardiocerebral Effects on the Temporal Organization of Blood Pressure in Patients with Multiple Sclerosis Living in the North (pp. 141-143)