AEDG Peptide Regulates the Expression of Circadian Genes Clock, Cry2, Csnk1e in Human Immune Cells (pp. 189-191)
Authors: Vladimir Khavinson, Natalia Linkova, and Oleg Ivko
Abstract: The pineal hormone melatonin (MT) is an essential regulator of circadian rhythms. MT activates circadian genes Bmal, Clock, Per, Cry due to its effect on membrane or nuclear receptors MT1 and MT2, or due to a direct effect on transcription factors [2, 4, 5]. It was found that MT synthesis is regulated by the polypeptide complex of epiphysis (Epithalamin) [1, 3]. AEDG peptide, which is a part of epithalamin, regulates MT synthesis and possesses a wide range of physiological properties similar to this hormone [1, 3]. This study aims to find out the effect of AEDG on the expression of circadian genes Clock, Cry2, and Csnk1e in human immune cells.
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