Character of the Daily Dynamics of a Number of Morphometric Parameters of Hepatocytes of Wistar Rats at Chronic Alcohol Intoxication (pp. 215-217)
Authors: Y. A. Kirillov, M. A. Kozlova, L. A. Makartseva, D. A. Areshidze, I. A. Chernov, and E. V. Shtemplevskaya
Abstract: The rhythmicity of functioning is characteristic for living matter at all levels of organization. Biorhythms of the eukaryotic organisms are genetically determined, however, they are plastic and are in close interaction with external and internal pacemakers, which have a modulating effect on them. Synchronization of the biorhythms of organisms with a temporal organization of the external environment is one of the mechanisms of maintaining homeostasis. At excessive exposure to stress factors or significant changes in the environment, desynchronosis can occur, which in general opinion is characterized by a violation in parameters of individual biorhythms, the mismatch of phase relationships between various biorhythms within the organism (internal desynchronosis) and between the rhythms of the organism and cyclic environmental factors (external desynchronosis). Desynchronosis can also initiate the development of various diseases and pathological conditions. The most important type of biorhythm for mammals is the circadian rhythm (CR) associated with the change of day and night. This study aims to find out the circadian rhythms in function of the hepatocytes in the day and night. Thus, it looks relevant to study the effect of chronic alcohol intoxication on the daily rhythm of a number of micro-morphometric indicators characterizing the morpho-functional state of the liver.
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