The Effect of Hypoxia on the Status of Peripheral Blood of Rats (pp. 255-256)
Authors: S. I. Mammadova
Abstract: The hypoxia represents universal pathological, accompanying and defining development of various pathology. Despite obvious distinction of triggers of formation of a hypoxia of exogenous and endogenous origin, metabolic shifts in the conditions of a lack of oxygen are stereotypic. They are connected with power shortage and strengthening of generation of active forms of oxygen, which leads to a membrane destruction, an excess lipoperoxidation, oxidizing modification of cellular proteins, start of programm-able cellular death subsequently. Disorganization of metabolism at a hypoxia is shown by violations of power exchange, biosynthesis of protein, DNA replication, change of sensitivity of membrane receptors and formation of intracellular secondary messengers. The brain, an endothelium of vessels of a myocardium, a kidney are most sensitive to deficiency of oxygen. Blood as liquid connecting body tissue, not only provides interrelation of all bodies and systems, being the indicator of a condition of an organism, but also itself directly reacts to deficiency of oxygen . Uniform elements of peripheral blood are an interesting object for study at a hypoxia as they differ from each other not only on the carried-out functions, but also the nature of exchange processes, extent of use of oxygen, ability to generation of AFK and resistance to them. The purpose of work was to study the indicators of peripheral blood during the general hypoxia.
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