Synchronization of Lipid Peroxidation Indicators in Saliva in Patients and Dentoalveolar Anomalies Treatment Using the Edgewise Technique (pp. 309-312)
Authors: L. F. Yagafarova, M. F. Kabirova, G. F. Minyakina, and T. Z. Kabirov
Abstract: One of the topical issues of modern orthodontics is timely prediction of the treatment results with the edgewise technique and the reduction of the risks of complications of the periodontal tissues and the oral mucosa . Despite the huge variety of pathogenetic and etiological factors the direct cause of the failure of long-term treatment results after treatment with the edgewise technique, according to most researchers, is the inflammatory process in perio-dontal tissues leading to the return of the teeth position to their original position before the treatment [1, 2]. Therefore, as laboratory findings indicating the risks of complications, a very objective research method is the products of free radical oxidation, in particular the products of lipid peroxidation. Lipid peroxidation is a chemical process, a cascade of reactions of converting lipids (supplied with food or synthesized in the body) with the participation of free radicals - active charged molecules. Since lipids are membrane components of all cells in the body, peroxidation reactions can lead to disruption of their structure and cell damage which is one of the mechanisms of the patho-genesis of a number of diseases.
Reactions of lipid peroxidation (LPO) constantly occur in the body in the norm to a certain extent, which should not be exceeded in order to avoid their damaging action. LPO plays an important role in the process of apoptosis, regulation of membrane structure and their functions (presentation of receptors, work of ion channels, release of biologically active substances, signal transmission between cells, etc.).
Excessive LPO activity can lead to the destruction of the cell membrane, the penetration or release of substances from it, which should not be normally, that leads to disruption of the vital activity of cells (their premature aging, destruction, altered functions before LPO). Studies aimed for identifying of products of LPO in a blood sample or saliva and their activity in order to assess the role of these substances in the reactions of oxidative damage to body cells (the so-called oxidative stress). Thus, the analysis of LPO reaction products makes it possible to understand the mechanisms of serious diseases development, to determine the so-called marker of oxidative stress in the body. If a violation is detected in a timely manner, it is possible to assign а therapy and prevent the development of the disease, its progression, and direct its course to a more favorable effect.
The expediency of such approach is determined by the fact that inflammation of the periodontal tissues is accompanied by the development of oxidative stress of varying severity even at the earliest stages [2, 3], which has been demonstrated in relation to inflammatory lesions of the periodontal tissues [2, 4]. A promising object of research in the diagnosis of complications and the prognosis of the treatment success with non-removable orthodontic equipment is saliva, which fully meets the requirements for modern methods of laboratory express diagnostics, including the diagnostics of oxidative metab-olism violations .
The aim of this research work is to study the level of lipid peroxidation products in saliva to develop a method for early diagnosis of complications and prognosis of successful treatment with the Edgewise technique.
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