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Motor Neuron Disease Research Progress
Retail Price: $225.00
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Editors: Raffaele L. Mancini
Book Description:
The motor neurone diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurones, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing.Neurological examination presents specific signs associated with upper and lower motor neurone degeneration. Signs of upper motor neurone damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neurone damage include weakness and muscle atrophy.
Every muscle group in the body requires both upper and lower motor neurones to function. It is a common misconception that "upper" motor neurones control the arms, whilst "lower" motor neurones control the legs. The signs described above can occur in any muscle group, including the arms, legs, torso, and bulbar region.

Symptoms usually present between the ages of 50-70, and include progressive weakness, muscle wasting, and muscle fasciculations; spasticity or stiffness in the arms and legs; and overactive tendon reflexes. Patients may present with symptoms as diverse as a dragging foot, unilateral muscle wasting in the hands, or slurred speech.

This new book presents the latest research from around the globe.

Table of Contents:
Preface

Chapter I - Current Concepts and Research in Multidisciplinary Management of Amyotrophic Lateral Sclerosis; pp. 1-50
(Rocha J.A., Department of Physical and Rehabilitation Medicine, Hospital de Săo Joăo, Portugal, McKim D.A., Department of Medicine, University of Ottawa, Canada)

Chapter II - Coupling ER stress to motor neuron degeneration in ALS; pp. 51-81
(Bradley J. Turner, Julie D. Atkin, Howard Florey Institute, University of Melbourne, Australia)

Chapter III - Transcranial Magnetic Stimulation in Amyotrophic Lateral Sclerosis: Diagnostic Value and Therapeutic Perspectives; pp. 83-108
(Raffaele Nardone, Frediano Tezzon, Department of Neurology, Franz Tappeiner Hospital, Italy, Günther Ladurner, Christian Doppler Clinic, Paracelsus Private Medical University, Austria)

Chapter IV - Mining genomic and proteomic data for biomarkers of amyotrophic lateral sclerosis and related motor neuron disease;
pp. 109-130
(Thomas J. Lukas, Teepu Siddique, Feinberg School of Medicine, Northwestern University, Chicago)

Chapter V - Amyotrophic Lateral Sclerosis: what goals for cell therapy?; pp. 131-144
(Letizia Mazzini, Department of Neurology, “Maggiore della Caritŕ” Hospital, University of Novara, Italy, Franca Fagioli, Department of Pediatrics, “Regina Margherita Children’s Hospital”, University of Turin, Italy)

Chapter VI - T cells may be credible therapeutic targets in amyotrophic lateral sclerosis; pp. 145-157
(Trygve Holmřy, Institute of Immunology, Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, Department of Neurology, Ullevĺl University Hospital, Norway)

Chapter VII - Mitochondrial involvement in amyotrophic lateral sclerosis; pp. 159-174
(Michelangelo Mancuso, Selina Piazza, Cecilia Carlesi, Department of Neuroscience, University of Pisa, Italy)

Chapter VIII - Activity-dependent conduction block detected by magnetic stimulation of the cervical root in multifocal motor neuropathy: magnetic fatigue test; pp. 175-196
(Hiroyuki Nodera, Ryuji Kaji, Department of Neurology, Graduate School of Medicine, Tokushima University, Japan)

Chapter IX - Oxidative DNA damage, DNA repair and Amyotrophic Lateral Sclerosis; pp. 197-214
(Fabio Coppedč, Luigi Murri, Department of Neurosciences, Neurological Clinic, University of Pisa, Italy, Lucia Migliore, Department of Human and Environmental Sciences, University of Pisa, Italy)

Chapter X - Post-Polio Syndrome: Recent Progress and Future Directions; pp. 215-234
(Rahnuma Wahid, Marie Chow, Katalin Pocsine, University of Arkansas for Medical Sciences, USA)

Chapter XI - Targeting the Inhibition of Cyclin-Dependent Kinases as a Potential Strategy for Treating Amyotrophic Lateral Sclerosis;
pp. 235-252
(Camins A., Alvira D., Facultat de Farmŕcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Spain, Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos Tercero, Spain, Verdaguer E., Departament de Farmacologia i Toxicologia, Spain)

Chapter XII - Recent Advances in Respiratory Care for Motor Neuron Disease; pp. 253-269
(Lo Coco Daniele, Dipartimento Universitario di Neuroscienze Cliniche (DUNC), University of Palermo, Italy, Marchese Santino, Lo Coco Albino, Pulmonary Department and Respiratory Intensive Care Unit, Ospedale Civico e Benfratelli, Italy)

Chapter XIII - Transcranial Magnetic Stimulation in Amyotrophic Lateral Scerlosis: A Review of Recent Developments; pp. 271-285
(M. Wittstock, A. Wolters, R. Benecke, Department of Neurology, University of Rostock, Germany)

Index

   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 978-1-60456-155-5
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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