Book Description:
Tumor “budding”, which is focused on in this book, is generally defined as an isolated single cancer cell or a cluster composed of a very small number of undifferentiated cancer cells in the stroma of the actively invasive front. The correlation of tumor budding with clinical outcome in colorectal cancer was first reported in the 1980s by Japanese surgeons. Since then, the clinical usefulness of this finding in colorectal cancer has been recognized in many countries. Its usefulness has been clarified not only as a prognostic factor and a potential parameter for a grading system, but also as an indicator for therapeutic decision making. Recently, more objective evaluation of tumor budding has been advocated, and the underlying mechanisms of tumor budding formation have been investigated at the molecular level. In this book, tumor budding in colorectal cancer is discussed from various perspectives. This book provides useful information for all investigators trying to deepen their understanding of colorectal cancer and develop evidence-based therapeutic strategies.

Table of Contents:
Chapter 1. Foreword (Yutaka Atomi (Kyorin University, Tokyo, Japan); Chapter 2. Preface (Tetsuichiro Muto, Cancer Institute Hospital, Tokyo, Japan; Hidetaka Mochizuki, National Defence Medical College, Tokorozawa, Japan; Tadahiko Masaki, Kyorin University, Tokyo, Japan); Chapter 3. Historical Aspects of Tumor Budding. 3.1. In the Field of Gastrointestinal Pathology (Kazuhito Ichikawa and Takahiro Fujimori, Dokkyo University, Tokyo, Japan); 3.2. In the Field of Colorectal Surgery (Kazuo Hase, Self-Defense Forces Central Hospital, Tokyo, Japan); Chapter 4. Basic Research. 4.1. Molecular Mechanisms Underlying Colorectal Carcinogenesis (Youichi Furukawa, University of Tokyo, Tokyo, Japan); 4.2. Beta-Catenin and Tumor Budding (Thomas Brabletz, University of Erlangen, Nuremberg, Germany); Chapter 5. Pathological Session. 5.1. Molecular and Pathological Aspects of Tumor Budding (Jeremy Jass, University of Queensland, Brisbane, Australia); 5.2. Significance of Tumor Budding in Early Colorectal Cancer Based on Micromorphologic and Statistical Studies (Kazuo Shirouzu, Kurume University, Fukuoka, Japan); 5.3. Aggressive and Non-aggressive Tumor Budding in Colorectal Cancers (Katarzyna Guziåƒska-Ustymowicz, Medical University of Białystok, Białystok, Poland); 5.4. Cohort Migration and IQGAP1 (Kazuki Nabeshima, Fukuoka University, Fukuoka, Japan); Chapter 6. Clinical research. 6.1. New Prognostic Markers in Submucosally Invasive Colorectal Carcinomas – Clinical Implication of Tumor Budding (Tadahiko Masaki, Kyorin University, Tokyo, Japan); 6.2. Tumor Budding in Advanced Rectal Carcinoma (Hideki Ueno and Hidetaka Mochizuki, National Defense Medical College, Tokorozawa, Japan); 6.3. Molecular Pathologic Application as a Predictor of Lymph Node Metastasis in Submucosal Colorectal Carcinoma - Implication of Immunohistochemical Alterations at the Deepest Invasive Margin (Shinji Tanaka, Hiroshima University, Tokyo, Japan); Index.