Book Description:
Stress is an adaptive response, that has developed throughout evolution, and is associated with multiple changes in the biochemistry, histology and physiology of an organism. As stress may induce or contribute to multiple neuropsychiatric disorders, the rigorous investigation of the neural substrates of stress has become a critical endeavor of contemporary biomedical science. This book explores the physiological responses that researchers have attempted to assess in stress-evoked behavioral changes, using both human and animal “experimental” models in clinical and non-clinical research. Though all aspects of the field have their challenges, animal experimental research of stress is a particularly difficult but meaningful task. This book provides succinct and relevant summaries of progress in the area of assessing stress response and the conditions contributing to it.

Table of Contents:
Preface

Chapter 1 - Studying Behavior in Stress Research - Not as Easy as One Would Think; pp. 1-22
(Roza Czabak-Garbacz, Department of Human Physiology of Medical University Lublin, Poland)

Chapter 2 - Development and Validation of Alternative Animal Models
of Anxiety and Depression Using Domestic Fowl; pp. 23-54
(Matthew W. Feltenstein, Department of Neurosciences, Medical University of South Carolina, USA, Kenneth J. Sufka, Research Inst. for Pharmaceutical Sciences, University of Mississippi, USA)

Chapter 3 - Animal Models of Anxiety: Examining Their Validity, Utility and Ethical Characteristics; pp. 55-71
(Jason E. Warnick, Department of Behavioral Sciences, Arkansas Tech University, USA and Kenneth J. Sufka)

Chapter 4 - The Open-field Model of Emotional Reactivity and Progress in the Molecular Genetics of Fear; pp. 73-96
(Saffron A.G. Willis-Owen, MA, D.Phil Imperial College, London,UK)

Chapter 5 - Mouse Lines Selected for Difference in Sensitivity to ß-CCM Also Differ in Spatial Memory, Corticosterone Activation and Fear Reactivity; pp. 97-109
(Daniel Beracochea, CNIC, Lab. de Neurosciences Intégratives et Cognitives, Universités de Bordeaux, Bâtiment Biologie Animale, France, Patrice Venault, CNRS UMR 7593 "Vulnérabilité, Adaptation et sychopathologie", CHU Pitié-Salpêtrière, France, Christophe Pierard, MASSA, Physiologie Intégrée, France and Georges Chapouthier, CNRS UMR 7593 "Vulnérabilité, Adaptation et sychopathologie", CHU Pitié-Salpêtrière, France)

Chapter 6 - Optimization of the Chronic Depression Model in C57 BL/6 Mice: Evidences For Improved Validity; pp. 111-157
(Tatyana Strekalova, Department of Psychiatry and Psychotherapy, RWTH Aachen University, Germany)

Chapter 7 - Domain-oriented Analysis for Understanding Molecular Interactions and Translating Animal Genetic Models into Neuropsychiatric Disorders: Focus on Serotonin Transporter and BDNF; pp. 159-183
(Allan V. Kalueff, Renee F. Ren-Patterson, Justin L. LaPorte and Dennis L. Murphy, Lab. of Clinical Science, National Inst.of Mental Health, USA)

Chapter 8 - Impaired Function of Phosphodiesterase 4B in Mutated Disc1 Mice Leads to Development of Pronounced Depression-like Behavior With Mild Expression of Schizophrenia-like Phenotype;
pp. 185-209
(Tatiana V. Lipina, Steven J. Clapcote, Kirsty Millar and David J. Porteous, Medical Genetics Section, University of Edinburgh Centre for Molecular Medicine, UK, et al.)

Index