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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.Myelin Basic Protein
05.New Research on Genomic Instability
06.Developmental Gene Expression Regulation
07.Lecture Notes on Computational Mutation
08.Fragile Sites: New Discoveries and Changing Perspectives
09.Progress in Stem Cell Applications
10.Genetic Vectors Research Focus
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New Research on DNA Damage
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Editors: Honoka Kimura and Aoi Suzuki
Book Description:
DNA damage, due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumor suppressor genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumor formation.
The vast majority of DNA damage affects the primary structure of the double helix; that is, the bases themselves are chemically modified. These modifications can in turn disrupt the molecules' regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. Unlike proteins and RNA, DNA usually lacks tertiary structure and therefore damage or disturbance does not occur at that level. DNA is, however, supercoiled and wound around "packaging" proteins called histones (in eukaryotes), and both superstructures are vulnerable to the effects of DNA damage. This new book presents the latest research in the field.

Please click on a chapter below to purchase separately

Chapter 1 - Cancer and Aging as Consequences of Un-Repaired DNA Damage (pp. 1-47)
Authors / Editors: (Harris Bernstein, Departments of Cell Biology and Anatomy, Arizona Cancer Center, College of Medicine, University of Arizona, Claire M. Payne, Departments of Cell Biology and Anatomy, Internal Medicine, Arizona Cancer Center, College of Medicine, University of Arizona, Carol Bernstein, Departments of Cell Biology and Anatomy, Section of Hematology/Oncology, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona, USA)
***Open Access Chapter. Free Download Available***

Chapter 2 - DNA Adductomics: Global Assessment of DNA Damage (pp. 49-60)
Authors / Editors: (Robert A. Kanaly, Laboratories of Environmental Microbiology and Molecular Toxicology, Dept. of Environmental Biosciences, Yokohama City Univ., Yokohama, Japan, Tomonari Matsuda, Dept. of Technology and Ecology, Graduate School of Global Environmental Studies, Kyoto Univ., Kyoto, Japan)

Chapter 3 - Radiation-Induced DNA Damage Responses as Novel Targets in Cancer Treatments (pp. 61-97)
Authors / Editors: (Wei-Dong Wang, Zheng-tang Chen, Department of Radiation Oncology, Cancer Institute of PLA, Xinqiao Hospital, Rong Li,Institute of Combined Injuries, College of Preventive Medicine, Third Military Medical University, China)

Chapter 4 - BRIT1, A Novel DNA Damage Responsive Protein Dysfunctioned in Primary Microcephaly and Cancer (pp. 99-112)
Authors / Editors: (Guang Peng, Shiaw Yih Lin, Department of Systems Biology, The University of Texas, Anderson Cancer Center, USA)

Chapter 5 - Polymorphisms in Genes Involved in DNA-Damage Processing and Their Effect on Cancer Risk (pp. 113-124)
Authors / Editors: (G. Iarmarcovai, A. Botta, T. Orsière, Laboratory of Biogenotoxicology and Environmental Mutagenesis, Faculty of Medecine, Université de la Méditerranée, France, S. Bonassi, Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy, R.A. Baan, Carcinogen Identification and Evaluation Group, WHO - International Agency for Research on Cancer, France)

Chapter 6 - HTLV-I Tax Promotes Genomic Instability by Interfering with Repair of DNA Breaks (pp. 125-144)
Authors / Editors: (Razvan I. Ducu, Susan J. Marriott, Department of Molecular Virology and Microbiology, Houston, USA)

Chapter 7 - Genotoxicity and Biomonitoring: Micronuclei in Peripheral Blood and Epithelial Cells (pp. 145-182)
Authors / Editors: (Belinda C. Gómez-Meda, Instituto de Biología Molecular y Terapia Génica, División de Disciplinas Básicas para la Salud, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Ana L. Zamora-Perez Instituto de Investigación en Odontología, Departamento de Clínicas Odontológicas Integrales, División de Disciplinas Clínicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guillermo M. Zúñiga-González Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, México)

Chapter 8 - Assays for the Quantitative Characterization of Genomic, Mitochondrial and Plasmid DNA (pp. 183-195)
Authors / Editors: (Christos D. Georgiou, Ioannis Papapostolou, Nikolaos Patsoukis, Konstantinos Grintzalis, Department of Biology, Section of Genetics, Cell Biology and Development, University of Patras, Greece)

Chapter 9 - DNA Damage through Photo-Induced Electron Transfer and Photosensitized Generation of Reactive Oxygen Species (pp. 197-219)
Authors / Editors: (Kazutaka Hirakawa, Department of Basic Engineering, Faculty of Engineering, Shizuoka University, Japan)

Chapter 10 - Consecutive Adenine Sequences Serve as Potential Targets in Photosensitized Oxidative DNA Damage (pp. 221-235)
Authors / Editors: (Kiyohiko Kawai, The Institute of Scientific and Industrial Research, Osaka University, Tetsuro Majima, The Institute of Scientific and Industrial Research, Japan)

Chapter 11 - A Novel Methodology to Characterize DNA Damage Utilizing Phosphodiesterase I Function (pp. 237-253)
Authors / Editors: (Ken Akamatsu, Radiation Effect Analysis Group, Nuclear Science and Engineering Directorate, Japan)

Chapter 12 - Factors Governing the Recurrence and Breakpoint Distribution of Chromosomal Translocations in Human Tumors (pp. 255-263)
Authors / Editors: (Francisco J. Novo, Department of Genetics, University of Navarra Spain)

Chapter 13 - Current Knowledge on Lead as an Inducer of Human DNA Damage (pp. 265-285)
Authors / Editors: (Joana Roma-Torres, Portuguese National Institute of Health, Centre of Environmental and Occupational Health, Portugal)

Chapter 14 - DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium (pp. 287-304)
Authors / Editors: (Emil Rudolf, Vera Králová, Ladislava Schroterová, Miroslav Cervinka, Department of Medical Biology and Genetics, Charles University in Prague, Faculty of Medicine in Hradec Králove, Sokolká, Kmil Rudolf, Department of Rheumatology and Clinical Pharmacology, Faculty Teaching Hospital in Hradec Králove, Sokolska, Czech Republic)

Chapter 15 - Comparison of DNA Damage and the Expression of Repair Related Molecules, Including DNA Polymerase-β, APE/ref-1, PCNA, and GADD45, in Human T and B Lymphocytes Exposed to Hydrogen Peroxide and Methyl Methanesulfonate (pp. 305-318)
Authors / Editors: (Eunkyung Cho, Graduate School of Medicine, Korea Universty,So-Young Park, Environmental Toxico-Genomic and Proteomic Center, College of Medicine, Korea University, Donggeun Sul, Graduate School of Medicine, Korea Universty, Environmental Toxico-Genomic and Proteomic Center, College of Medicine, Korea University, Korea)

Chapter 16 - Mutational Hotspots of TP53 Gene Associated to DNA Damage (pp. 319-342)
Authors / Editors: (Angélica Rangel-Lopez, José Ramon Pniagua-Sierra, Unidad de Investigacion Medica en Enfermedades Nefrològicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico)

Chapter 17 - Mutation Detection in the TP53 Gene: Alternatives in Point Mutation Technologies (pp. 343-345)
Authors / Editors: (Rangel-Lòpez Angélica, Unidad de Investigacion Médica en Enfermedades Oncològicas, Hospital de Oncologìa, Centro Médico Nacional S XXI, laboratorio de Tecnologia del DNA, Departamento de Bioquimica, Escuela Nacional de Ciencias Biològicas, Méndez-Tenorio Alfonso, Laboratorio de Tecnologìa del DNA, Departamento de Bioquìmica, Escuela Nacional de Ciencias Biològicas, Salcedo Mauricio, Unidad de Investigaciòn Médica en Enfermedades Oncològicas, Hospital de Oncologia, México)

Chapter 18 - The Induction and Repair of DNA-Protein Crosslinks in Mammalian Cells (pp. 347-378)
Authors / Editors: (Sharon Barker, Michael Weinfeld and David Murray, Department of Oncology, Division of Experimental Oncology, University of Alberta, Edmonton, Alberta, Canada)

   Binding: Hardcover
   Pub. Date: 2008
   Pages: 7 x 10, 410 pp.
   ISBN: 978-1-60456-581-2
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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