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01.D-Amino Acids: A New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols
02.Cellular Signaling and Apoptosis Research
03.Cell Apoptosis Research Trends
04.Stem Cells and Cancer
05.Cell Growth Processes: New Research
06.Histological and Serological Tumor Markers and Gene Expression and Their Clinical Usefulness in Cancers
07.Foldases: Enzymes Catalyzing Protein Folding
08.Trends in Signal Transduction Research
09.Mast Cells: Roles, Interactions and Disorders
10.Stem Cell Research Developments
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Stem Cells Research Compendium, Volume 1
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Editors: Prasad S. Koka (Laboratory of Stem Cell Biology, Torrey Pines Institute for Molecular Studies, San Diego, CA , USA)
Book Description:
The two broad categories of mammalian stem cells exist: embryonic stem cells, derived from blastocysts, and adult stem cells, which are found in adult tissues. In a developing embryo, stem cells are able to differentiate into all of the specialised embryonic tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialised cells.

As stem cells can be readily grown and transformed into specialised tissues such as muscles or nerves through cell culture, their use in medical therapies has been proposed. In particular, embryonic cell lines, autologous embryonic stem cells generated therapeutic cloning, and highly plastic adult stem cells from the umbilical cord blood or bone marrow are touted as promising candidates.

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson’s disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, and Alzheimer’s disease. Stem cells are self-renewing, unspecialized cells that can give rise to multiple types all of specialized cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, fetal tissue and embryonic sources.

This new book presents leading research from around the world in this field which is of interest to so many and presents so many hopes.

Table of Contents:

Foreword: Stem Cells; pp. 1-2

Chapter 1 - Megakaryocytopoiesis: From Marrow Stem Cells to Circulating Platelets; pp. 3-32
(Aaron Tomer and Varda Deutsch)

Chapter 2 - A Novel Serum-Free Culture System for the Analysis of
Human Hematopoietic Progenitor Cells; pp. 33-47
(Mary Beth Hanley, Elizabeth Sinclair, Willis H. Navarro,
Mary E. Keir, and Joseph M. McCune)

Chapter 3 - Potential of Bone Marrow Stromal Stem Cells to Repair Bone Defects and Fractures; pp. 49-63
(Stan Gronthos and Andrew C.W. Zannettino)

Chapter 4 - Adult Neural Stem Cells and Cellular Therapy; pp. 65-77
(Philippe Taupin)

Chapter 5 - The Cardiogenic Potential of Mouse and Human Embryonic Stem Cells: Cognitive Research to Envision the Therapeutic Use of the Cells; pp. 79-91
(Michel Pucéat)

Chapter 6 - Hemopoietic Stem Cells and Autoimmunity: Impaired
Mechanisms of Thymic Selection or Genetic Predisposition?; pp. 93-118
(Masha Fridkis-Hareli, Joaquin Zúñiga and Edmond J. Yunis)

Chapter 7 - Control of Tissue Regeneration through Oxygen Concentrations; pp. 119-131
(Jessica A. Shafer, Alan R. Davis and Elizabeth A. Olmsted-Davis)

Chapter 8 - Control of Thymocyte Proliferation and Thymus Organ Size by CDK Inhibitors; pp. 133-141
(Grigoriy I. Kovalev, Tamara D. Simon, V. McNeil Coffield, Yue Xiong, David S. Franklin, and Lishan Su)

Chapter 9 - Human Embryonic Stem Cell-Derived Cardiomyocytes: Therapeutic Potentials and Limitations; pp. 149-169
(Ronald A. Li, Jennifer C. Moore, Yelena S. Tarasova, and Kenneth R. Boheler)

Chapter 10 - Stem Cells in Aging: Influence of Ontogenic, Genetic and Environmental Factors; pp. 177-200
(Edmond J. Yunis, Joaquin Zuniga, Prasad S. Koka, Zaheed Husain, Viviana Romero, Joel N. H. Stern, and Masha Fridkis-Hareli)

Chapter 11 - Stem Cells in Aging: Contribution of The Immune System; pp. 201-231
(Masha Fridkis-Hareli, Joaquin Zuniga, and Edmond J. Yunis)

Chapter 12 - Diminished Gene Expression in Human Mesenchymal Stem Cells by Mutation of Focal Adhesion Kinase Signalling; pp. 233-243
(William A. Williams, Nicole E. Schapiro, Samuel R. Christy,

Chapter 13 - Stem Cells as Therapy for Cardiovascular Disease: Lost in Translation?; pp. 245-268
(Keith A. Robinson, Nicolas A. F. Chronos and Nadine Weich)

Chapter 14 - Human Chimerism and Tetragametism: Relevance of Embryonic or/and Hematopoietic Stem Cells; pp. 269-287
(Edmond J. Yunis, Joaquin Zuniga, Viviana Romero and Emilio J. Yunis)

Chapter 15 - Mathematical Modeling of T Cell Differentiation from Hemopoietic Stem Cell Progenitors; pp. 289-307
(Ramit Mehr and Masha Fridkis-Hareli)

Chapter 16 - The Importance of Large Animal Models in Stem Cell Research; pp. 309-328
(Amy M. Revenis and Robert E. Donahue)

Chapter 17 - Hypoxia Expands Primitive Hematopoietic Progenitor Cells From Mouse Bone Marrow During In-Vitro Culture and Preserves The Colony-Forming Ability; pp. 329-342
(Pernilla Eliasson, Richard Karlsson and Jan-Ingvar Jönsson)

Chapter 18 - A Versatile Method for Differentiation of Multiple Neuronal Subtypes from Mouse Embryonic Stem Cells; pp. 343-356
(Silvia Parisi, Enza Lonardo, Annalisa Fico, Stefania Filosa and Gabriella Minchiotti)

Chapter 19 - Signaling Pathways Involved in the Maintenance of Human Embryonic Stem Cells; pp. 357-372
(Raymond Wong and Alice Pébay)

Chapter 20 - Chimeric SCID-hu Model as a Human Hematopoietic Stem Cell Host That Recapitulates the Effects of HIV-1 on Bone Marrow Progenitors in Infected Patients; pp. 373-396
(I. Birgitta Sundell and Prasad S. Koka)

Chapter 21 - The Effects of EX Vivo Expansion on the Differentiation of Umbilical Cord Blood-Derived CD34+ Cells; pp. 397-406
(Korashon L. Watts, Roger Tran-Son-Taya and Vijay S. Reddy)


   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 978-1-60456-599-7
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Stem Cells Research Compendium, Volume 1