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Insulin Resistance: New Research
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Editors: E. B. Yao
Book Description:
Insulin resistance is defined as an impaired biological response to either exogenous or endogenous insulin. It is an increasingly prevalent disorder in the developed countries and is known as a high risk factor for both cardiovascular diseases and malignancies.

This book describes the endocrine disorders that are associated with changes in insulin sensitivity, often resulting in clinical consequences such as impaired glucose tolerance or secondary diabetes mellitus. The main components of a pathological condition known as metabolic syndrome (MS) or syndrome X is also described, including insulin resistance, type II diabetes, hypertension, central obesity, dyslipidemia, and nephropathy.

The treatment of type II diabetes is examined, including the adjustments to changes in insulin resistance and secretion and to variations in basal and prandial glucose along the diabetes continuum. The prevalence of insulin resistance among children and adolescents is also looked at, including insulin resistance in childhood cancer survivors. In addition, the association between insulin resistance and oral cancer risk (i.e. smoking) is addressed, as well as the roles of insulin resistance and sympathetic nerve activity in obesity, hypertension, Turner syndrome and liver disease. The association between non-alcoholic fatty liver disease (NAFLD) and insulin resistance, and the pathogenetic and therapeutic implications are also addressed.

Table of Contents:

Research and Review Studies

Insulin Resistance in Endocrine Disorders;pp. 1-47
(Jana Vrbikova, Sona Stanicka, Karel Vondra, Katerina Zajickova, Luboslav Starka, Institute of Endocrinology, Prague, Czech Republic)

Insulin Resistance and the Metabolic Syndrome;pp. 49-97
(Guadalupe Banos, Mohammad El Hafidi, Dept. of Biochemistry, Israel Perez-Torres, Dept. of Pathology, Veronica Guarner, Dept. of Physiology, Instituto Nacional de Cardiologia, "Ignacio Chavez", Mexico, D.F.)

^Fetuin-A, a Novel Regulator of Insulin Action: Role in Insulin Resistance;pp. 99-116
(Suresh T. Mathews and Teayoun Kim, Department of Nutrition and Food Science, Boshell Diabetes and Metabolic Diseases Research Program,
Auburn University, Auburn, AL)

Insulin Resistance and Endothelial Dysfunction: An Unhappy Union;pp. 117-135
(Micaela Iantorno, Ranganath Muniyappa, Michael J. Quon*, Diabetes Unit, National Center for Complementary and Alternative Medicine, *National Institutes of Health, Bethesda, MD)

Treatment of Type 2 Diabetes: Adjustments to Changes in Insulin Resistance and Secretion and to Variations in Basal and Prandial Glucose along the Diabetes Continuum;pp. 137-164
(L. Monnier, C. Colette, Laboratory of Human Nutrition, Univ. Institute of Clinical Research, Montpellier Cedex, France, DR.Owens, Diabetes Research Unit, Academic Centre, Univ. Hospital Llandough, Cardiff, UK)

Is the Metabolic Syndrome Associated per se with Chronic Inflammatio;pp. 165-186
(Magdalena Olszanecka-Glinianowicz, Barbara Zahorska-Markiewicz, Piotr Kocelak, Joanna Janowska, Dept. of Pathophysiology Medical Univ. of Silesia, Katowice, Poland, Adam Szromek, The Silesian Univ. of Technology, Faculty of Organization and Management, Gliwice, Poland)

The Metabolic Syndrome as a Concept of Adipose Tissue Disease;pp. 187-200
(Eiji Oda, Tachikawa Medical Center, Niigata, Japan)

Surveillance of Insulin Resistance in Children and Adolescents;pp. 201-215
(Fernando Guerrero-Romero, Martha Rodriguez-Moran, Luis E. Simental-Mendia, Biomedical Research Unit, Mexican Social Security Institute, Nucleus of Research and Clinical Diagnosis (NIDIAC), Durango, Mexico)

The Causes of the Metabolic Syndrome - An Asian Perspective;pp. 217-233
(Bernard M Y Cheung, Dept. of Clinical Pharmacology, G. Neil Thomas, Dept. of Public Health and Epidemiology, Univ. of Birmingham, UK)

Insulin Resistance in Childhood Cancer Survivors: A Link between Metabolic Syndrome Features;pp. 235-251
(Spinola-Castro AM, Siviero-Miachon AA, Dept. of Pediatrics, Pediatric Endocrinology Division, School of Medicine, Federal Univ. of Sao Paulo, Sao Paulo, Brazil, Guerra-Junior G, Dept. of Pediatrics, Pediatric Endocrinology Division, Faculty of Medical Sciences, Univ. of Campinas, Campinas, SP, Brazil, Geloneze-Neto B, Dept. of Medical Clinic, Endocrinology Division, Faculty of Medical Sciences, Univ. of Campinas, SP, Brazil)

Insulin Resistance and Oral Cancer Risk;pp. 253-275
(Zsuzsanna Suba, Dept. of Oral and Maxillofacial Surgery, Univ. of Budapest, Hungary)

The Roles of Insulin Resistance and Sympathetic Nerve Activity in Obesity and Hypertension - which comes first in Hypertension and Obesity?;pp. 277-300
(Kazuko Masuo, Gavin W. Lambert, and Murray D. Esler, Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia)

Insulin Resistance: New Research (Insulin Resistance and Liver Disease);pp. 301-323
(Masahide Hamaguchi, Michiaki Fukui, and Yutaka Kawahito, Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural Univ. of Medicine, Kyoto, Japan)

Turner Syndrome and Insulin Resistance: Reviewing this Complex Association;pp. 325-342
(Guerra-Junior, G, Maciel-Guerra, AT, Baldin, AD, Interdisciplinary Group for Study on Sex Determination and Differentiation - Faculty of Medical Sciences, Univ. of Campinas (UNICAMP), Campinas, SP, Brazil, Siviero-Miachon, AA, Spinola-Castro, AM, Dept. of Pediatrics, Univ. of Pediatric Endocrinology, School of Medicine, Federal Univ. of Sao Paulo, Sao Paulo, SP, Brazil)

Association between Non-Alcoholic Fatty Liver Disease (NAFLD) and Insulin Resistance: Pathogenetic and Therapeutic Implications;pp. 343-360
(Alisi Anna, Manco Melania, Ciampalini Paolo, Marcellini Matilde, Nobili Valerio, Liver Unit, "Bambino Gesu" Children's Hospital and Research Institute, Rome, Italy)

Short Communications

Association of Plasma Homocysteine to Insulin Resistance and Metabolic Syndrome Components in Healthy Omnivores and Vegetarians;pp. 361-374
(Katarina Sebekova, Peter Boor, Martina Valachovicova, Research Base of Slovak Medical Univ., Bratislava, Slovakia, and Pavol Blazicek, Hospital of Ministry of Defence of Slovak Republic, Bratislava, Slovakia, et al.)

Effect of Insulin Resistance on Coronary In-Stent Restenosis;pp. 375-387
(Kazuaki Nishio, Noburu Konno, Youichi Kobayashi, Third Department of Internal Medicine, School of Medicine, Showa University, Tokyo, Japan)

MRI Measurement of Visceral Fat & Epicardial Adipose Tissue;pp. 389-408
(Shigeko Tanaka, Dept. of Radiology, Tsutomu Nomura, Dept. of Gastroenterology, Masuki Mori, Dept. of Cardiology, Wakakusa Daiichi Hospital, Osaka, Japan et al.)

Expression of Inflammatory Molecules in an Experimental Vascular Remodeling Model;pp. 409-421
(Nicolas Renna and Roberto M. Miatello, Dept. of Pathology - School of Medical Sciences, National Univ. of Cuyo, Mendoza, Argentina)

Methods of Insulin Resistance Assessment;pp. 423-431
(Georgia Argyrakopoulou, Othon Michail, Nicholas Tentolouris, First Dept. of Propaedeutic Medicine, Athens Univ. Medical School, Athens, Greece)

Insulin-Sensitizing Effects of Telmisartan via Peroxisome Proliferator-Activated Receptor-y Activation;pp. 433-438
(Sho-ichi Yamagishi, Kazuo Nakamura, Takanori Matsui, Dept. of Medicine, Hiroyoshi Inoue, Radioisotope Institute for Basic and Clinical Medicine, Kurume Univ. School of Medicine, Kurume, Japan)


   Binding: Hardcover
   Pub. Date: 2009
   Pages: 480 pp.
   ISBN: 978-1-60692-332-0
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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